Press release
TissueCypher® Barrett’s Esophagus Test Outperformed Standard of Care in Risk-Stratifying Patients with Barrett’s Esophagus
The study, published in Gastroenterology, shows TissueCypher can increase the detection of Barrett’s esophagus (BE) patients with an initial diagnosis of
About this update from Castle Biosciences, Inc.
[{"type":"text","content":"\nThe study, published in Gastroenterology, shows TissueCypher can increase the detection of Barrett’s esophagus (BE) patients with an initial diagnosis of low-grade dysplasia (LGD) who will progress to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)\n\n\n FRIENDSWOOD, Texas--(BUSINESS WIRE)--\nCastle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of data demonstrating that the TissueCypher® Barrett’s Esophagus test outperformed standard of care pathology review in predicting malignant progression to HGD and EAC in BE patients with an initial diagnosis of LGD. The study findings are available online in Gastroenterology.1\n\n\n“The significant variability in pathology diagnoses of Barrett’s esophagus is compounded by the challenges of effectively predicting which patients among the hundreds of thousands who are diagnosed each year are most likely to progress to advanced forms of the disease and/or cancer,” said Jacques Bergman, M.D., Ph.D., study author, leading BE expert and professor of gastrointestinal endoscopy at the University of Amsterdam and the Amsterdam University Medical Centers, the Netherlands. “TissueCypher has the ability to change this paradigm. Using Artificial Intelligence, the test looks deeper into in a patient’s disease than possible through traditional pathology review, providing objective information regarding a patient’s risk of progressing to esophageal cancer that can ensure early access to effective and possibly curative treatments.”\n\n\nThe study evaluated the risk-stratification performance of TissueCypher in 154 BE patients with an initial community-based diagnosis of LGD with known progression/non-progression outcomes who were prospectively followed as part of the Surveillance versus Radiofrequency Ablation (SURF) trial. The study aimed to compare the test’s performance against an international panel of 14 expert and 16 community-based, generalist pathologists from five countries.\n\n\nIn the study, the TissueCypher test demonstrated higher sensitivity in detecting patients who progressed to HGD/EAC when compared to the panel of pathologists (71% vs. mean 63%, range 33-88% across 30 pathologists; p=0.01186). Importantly, TissueCypher identified 43% of the progressors downstaged to NDBE by t...