Press release
Publication of Data from Prospective, Multicenter Study Demonstrates Positive Survival Outcomes in Patients with Low-Risk Melanoma Who Avoided Sentinel Lymph Node Biopsy with Information from Castle Biosciences’ DecisionDx®-Melanoma Test
Consistent with prior studies, published results from Castle’s DECIDE study show DecisionDx-Melanoma can both accurately identify patients with less than 5%
About this update from Castle Biosciences, Inc.
[{"type":"text","content":"Consistent with prior studies, published results from Castle’s DECIDE study show DecisionDx-Melanoma can both accurately identify patients with less than 5% risk of sentinel lymph node (SLN) positivity, who can safely consider forgoing the sentinel lymph node biopsy (SLNB) surgical procedure, and who are also unlikely to experience disease progression1,2 As of the last follow-up, all of the patients in the third study analysis with a low-risk DecisionDx-Melanoma test result (Class 1A) were recurrence free, regardless of SLN status3 FRIENDSWOOD, Texas, April 03, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the recent publication of two papers in the World Journal of Surgical Oncology and Cancer Medicine sharing reports from the prospective, multicenter DECIDE study demonstrating the significant impact of the Company’s DecisionDx-Melanoma test on SLNB decision-making for patients with melanoma.3,4 SLNB is a surgical procedure commonly used to determine whether a patient’s melanoma has spread to nearby lymph nodes. While useful in the prognosis of patients for whom cancer is found in the lymph nodes, SLNB returns a surgical result that is negative for metastasis in approximately 88% of patients who undergo the procedure.5 Current National Comprehensive Cancer Network® (NCCN) guidelines suggest forgoing SLNB when the likelihood of finding a positive SLN is less than 5%, considering SLNB when the risk is between 5-10% and offering the surgery when the likelihood of positivity is above 10%. Castle’s prospective, multicenter DECIDE study was designed to assess the performance of the DecisionDx-Melanoma test in guiding SLNB decisions in patients with T1-T2 tumors and following these patients’ long-term outcomes. “Decision-making for patients whose staging-based risk falls within or around the 5-10% threshold (i.e., patients with T1-T2 tumors) can be challenging. Our study findings underscore the strength of the DecisionDx-Melanoma test to accurately identify patients with T1-T2 tumors who have a low risk of metastasis and can safely forgo SLNB, within guideline recommendations, without experiencing a melanoma recurrence,” said J. Michael Guenther, M.D., lead study author and surgeon at St. Elizabeth Physicians in Edgewood, K...