Press release
Prospective, Multicenter Study Demonstrates That DecisionDx®-Melanoma Test Results Can Significantly Reduce the Number of Sentinel Lymph Node Biopsy (SLNB) Procedures Performed When Used Within the Context of Current Guidelines
FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care,
About this update from Castle Biosciences, Inc.
[{"type":"text","content":" FRIENDSWOOD, Texas--(BUSINESS WIRE)--\nCastle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of data from a prospective, multicenter study, called DECIDE.1,2 In the study, DecisionDx®-Melanoma test results influenced 85% of clinicians’ decisions regarding the sentinel lymph node biopsy (SLNB) surgical procedure. Additionally, use of the tests’ results within current guideline recommendations led to a significant reduction in SLNB procedures performed, demonstrating the potential clinical value of the test to guide risk-aligned patient care.\n\n“DecisionDx-Melanoma is the best-studied molecular test for use in cutaneous melanoma to date, with studies involving more than 10,000 research subjects. DecisionDx-Melanoma provides personalized information about a patient’s risk of sentinel lymph node (SLN) positivity to inform decisions about whether to safely forego or pursue an SLNB,” said Maki Yamamoto, M.D., board-certified surgical oncologist and associate professor of surgery at the University of California-Irvine School of Medicine in Orange, California. “The data from this prospective, multicenter study showed that clinicians who used the test performed fewer SLNBs overall, which can alleviate complication rates and high costs associated with the procedure, and focus surgical procedures on patients who have a greater likelihood of being SLN positive.”\n\n“We believe DecisionDx-Melanoma has the ability to influence management decisions based on ample evidence provided in more than 40 peer-reviewed studies and the experience of clinical use in more than 120,000 patients,\" said Robert Cook, Ph.D., senior vice president of research and development at Castle Biosciences. \"We also believe that the use of molecular tests to guide clinical decisions adds value that is independent from the clinicopathologic risk factors traditionally used in melanoma risk assessment. We are pleased the DECIDE study results showed that using our DecisionDx-Melanoma test in combination with clinicopathologic features demonstrated superiority over the use of clinicopathologic factors alone to guide appropriate decisions about SLNB use.”3\n\nStudy highlights:\n\n\nSLNB surgery is an invasive surgical procedure that is used for risk-stratification purposes; acco...