Press release
Data Presentation at 2023 Winter Clinical - Miami™ Highlights Use of DecisionDx®-Melanoma to Guide SLNB Surgery Decisions in Head and Neck Tumors
Additional presentation on Castle’s pipeline test for inflammatory skin diseases highlights unmet clinical need FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle
About this update from Castle Biosciences, Inc.
[{"type":"text","content":"\nAdditional presentation on Castle’s pipeline test for inflammatory skin diseases highlights unmet clinical need\n\n FRIENDSWOOD, Texas--(BUSINESS WIRE)--\nCastle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that new data on DecisionDx®-Melanoma and the Company’s pipeline test for inflammatory skin diseases was presented at the recent 2023 Winter Clinical - Miami™ conference.\n\nThe poster presentation for DecisionDx®-Melanoma strengthens the evidence supporting use of the test to provide risk stratification for patients in order to guide risk-appropriate sentinel lymph node biopsy (SLNB) surgery decisions. Additionally, the poster for Castle’s inflammatory skin disease pipeline test highlights feedback from clinicians regarding therapy selection strategies, informing the development of Castle’s pipeline test and supporting the unmet clinical need for a molecular test to guide therapeutic selection for patients with inflammatory skin diseases.\n\nDecisionDx®-Melanoma\n\nPoster title: The i31-gene expression profile test for cutaneous melanoma identifies patients with head and neck tumors who could forego sentinel lymph node biopsy\n\nIn the study, no patients who received a low-risk DecisionDx-Melanoma test result, which predicts a less than 5% risk of sentinel lymph node (SLN) positivity, had a positive SLNB. Additionally, the data showed that using DecisionDx-Melanoma to guide risk-aligned patient care could reduce the number of unnecessary SLNBs by 37% overall, 63% for T1a tumors and 50% for T1b tumors, specifically. In the study, DecisionDx-Melanoma achieved 100% sensitivity, demonstrating its potential to identify patients likely to experience SLN metastasis. This study involved patients with cutaneous melanoma (CM) tumors (T1-T2a) located in the head or neck region who had undergone SLNB (n=159). CM tumors on the head or neck tend to be more aggressive and pose unique challenges for SLNB surgery.\n\n“These data reinforce those from our recently published DECIDE study,1 showing that use of DecisionDx-Melanoma to inform decisions around the SLNB surgical procedure could reduce the number of unnecessary procedures performed, particularly in patients with a low risk of metastasis,” said Matthew Goldberg, M.D., F.A.A.D., board-certified dermatolo...