Castle Biosciences Presents New Data Demonstrating DecisionDx®-SCC Complements Current Risk Assessment Methods in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck

Data Presented at American Head & Neck Society (AHNS) 10th International Conference on Head and Neck Cancer

FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle Biosciences, Inc. (Nasdaq: CSTL), a dermatologic diagnostics company providing personalized genomic information to inform treatment decisions, today announced a podium presentation on its DecisionDx®-SCC test at the American Head & Neck Society (AHNS) 10th International Conference on Head and Neck Cancer, being held July 22-25, 2021.

DecisionDx-SCC is Castle’s prognostic 40-gene expression profile (GEP) test for patients diagnosed with high-risk cutaneous squamous cell carcinoma (SCC), designed to use a patient’s tumor biology to predict individual risk of metastasis for patients with SCC and one or more risk factors.

“Comparison of the 40-Gene Expression Profile Test with Clinicopathologic Risk Factor-Based Assessment to Improve Metastasis Risk Assessment in Cutaneous Squamous Cell Carcinoma of the Head and Neck” will be presented by Jason G. Newman, M.D., University of Pennsylvania Health System, Philadelphia, on July 23 at 3:30 p.m.-4:20 p.m. Central time.

“Study data demonstrate that DecisionDx-SCC is a valuable complement to traditional and trusted risk assessment systems, including the American Joint Committee on Cancer Eighth Edition (AJCC8) and Brigham and Women's Hospital (BWH) tumor (T) classification,” said Newman. “The data further demonstrate that Castle’s DecisionDx-SCC test can provide clinicians with additional information on a patient’s metastatic risk to help them make more informed choices about their treatment and follow-up care.”

Study methods and findings:

• Archival, primary tumor specimens and associated data from a cohort of 278 patients from 33 different clinical sites were included in the study; the patients had high-risk SCC located on the head or neck, and 54 patients (19.4%) developed regional and/or distant metastasis.
• All SCC tumor specimens were tested with DecisionDx-SCC and analyzed using Kaplan-Meier for metastasis-free survival (MFS) and Cox regression for risk of regional/distant metastasis.
• Patients who received a Class 1 (low biological risk), Class 2A (moderate biological risk) or Class 2B (high biological risk) DecisionDx-SCC result had significantly different three-year MFS rates (92.1%, 76.1% or 44.4%, respectively; p