Press release
Castle Biosciences' DecisionDx®-SCC Data Earns Top Five Abstract at NCCN 2025, Shows Significantly Enhanced Risk Stratification Beyond Current Staging Within NCCN Risk Groups
New, combined validation cohort of 1,412 patients with high-risk squamous cell carcinoma (SCC) demonstrates that the addition of DecisionDx-SCC to Brigham &
About this update from Castle Biosciences, Inc.
[{"type":"text","content":"New, combined validation cohort of 1,412 patients with high-risk squamous cell carcinoma (SCC) demonstrates that the addition of DecisionDx-SCC to Brigham & Women's Hospital (BWH) staging significantly refines metastatic risk prediction in patients classified as High-Risk and Very High-Risk by National Comprehensive Cancer Network (NCCN) guidelines to support improved, risk-aligned treatment pathway decisions Castle will also present new data showing DecisionDx®-Melanoma as a significant predictor of mortality in a real-world cohort of nearly 7,000 patients with early-stage cutaneous melanoma (CM), reinforcing its value in identifying patients who may benefit from treatment plan strategies to improve outcomes FRIENDSWOOD, Texas, March 28, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, will share new data on its risk-stratification tests for patients with skin cancers, DecisionDx-SCC and DecisionDx-Melanoma, via two poster presentations at the NCCN 2025 Annual Conference, being held March 28-30 in Orlando, Florida. As a top five, blue-ribbon abstract at the conference, Castle’s poster on DecisionDx-SCC will also be shared in a special oral presentation with the other top-scoring submissions. \"Our latest data at NCCN highlight the significant prognostic capabilities of DecisionDx-SCC and DecisionDx-Melanoma, demonstrating their ability to enhance risk stratification beyond traditional staging,” said Rebecca Critchley-Thorne, Ph.D., vice-president, research and development, of Castle Biosciences. “By providing critical insights into predicted metastatic risk and survival likelihood, these tests equip clinicians with actionable results to enable more precise, personalized treatment decisions that may help optimize patient management and care.” Castle’s posters will be available for viewing during the general poster sessions on March 28. As a top-scoring submission, Castle’s DecisionDx-SCC abstract will also be published in the print version of the JNCCN—Journal of the National Comprehensive Cancer Network. Additional details are included below: DecisionDx-SCC Poster 5: Metastasis-free Survival Prediction with the 40-gene Expression Profile Test in Patients with Cutaneous Squamous Cell Carcinoma Risk Stratified According to the National C...