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Caribou Biosciences Presents New Preclinical Data on CB-012, an Allogeneic Anti-CLL-1 CAR-T Cell Therapy, at the 2023 AACR Annual Meeting
-- CB-012 genome-edited armoring strategy significantly reduced tumor burden and improved overall survival in AML xenograft models -- -- CB-012 IND-enabling
About this update from Caribou Biosciences, Inc.
[{"type":"text","content":"-- CB-012 genome-edited armoring strategy significantly reduced tumor burden and improved overall survival in AML xenograft models -- -- CB-012 IND-enabling studies ongoing; IND submission in r/r AML planned for H2 2023 -- BERKELEY, Calif., April 17, 2023 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (Nasdaq: CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, today presents a poster of preclinical data demonstrating the promise of CB-012, a next-generation CRISPR-edited allogeneic anti-CLL-1 CAR-T cell therapy, as a therapeutic candidate for adult patients with relapsed or refractory acute myeloid leukemia (r/r AML). The presentation takes place at the 2023 American Association for Cancer Research (AACR) Annual Meeting today from 1:30 pm to 5:00 pm EDT at the Orange County Convention Center, Orlando, Florida. “CLL-1 is a compelling target for AML because it is highly expressed on myeloid cancer cells and is enriched on leukemic stem cells, but it is not expressed on hematopoietic stem cells,” said Steve Kanner, PhD, Caribou’s chief scientific officer. “CB-012 is engineered with 5 edits, using our Cas12a chRDNA technology, which armor the CAR-T cells for improved antitumor activity through checkpoint disruption and immune cloaking. The preclinical data in the poster demonstrate that CB-012 exhibits enhanced antitumor activity against established AML xenografts.” Caribou’s patented next-generation CRISPR Cas12a chRDNA genome-editing technology platform, which maintains high genomic integrity and significantly improves the specificity of genome edits, was used to engineer the 5 genome edits implemented in the manufacture of CB-012. CB-012 is the first allogeneic CAR-T cell therapy, to Caribou’s knowledge, with both checkpoint disruption, through a PD-1 knockout (KO), and immune cloaking, through a B2M KO and B2M–HLA-E fusion transgene insertion. These armoring strategies were designed to promote the durability of antitumor activity. Preclinical data presented at the AACR meeting show: CB-012 targets, becomes activated, proliferates, and demonstrates antitumor activity against a broad panel of AML cancer cell linesImmune cloaking protects CB-012 from NK cell-mediated cytotoxicityMice harbouring AML xenograft models treated with CB-012 having a PD-1 KO showed extended survival relative to mice injected w...