Business

Capricor Therapeutics Announces Positive 4-Year Data from HOPE-2 Open-Label Extension Study of Deramiocel in Duchenne Muscular Dystrophy

Four-year data show preservation of cardiac function, including LVEFSkeletal muscle disease progression continues to slow with extended treatment (PUL v2.0)Deramiocel’s long-term safety profile remains favorableResults presented at PPMD’s 2025 Annual Conference SAN DIEGO, June 20, 2025 (GLOBE NEWSWIRE) -- Capricor Therapeutics (NASDAQ: CAPR), a biotechnology company developing transformative cell and exosome-based therapeutics for rare diseases, today announced positive four-year safety and effi

articleCapricor Therapeutics, Inc.June 20, 20257/company/capricor-therapeutics-inc/news/capricor-therapeutics-announces-positive-4-132500842
Capricor Therapeutics Announces Positive 4-Year Data from HOPE-2 Open-Label Extension Study of Deramiocel in Duchenne Muscular Dystrophy

About this update from Capricor Therapeutics, Inc.

[{"type":"image","alt":"Capricor Therapeutics","displaySize":"","headline":null,"caption":"Capricor Therapeutics","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":107,"url":"https://media.zenfs.com/en/globenewswire.com/9425e1c34a8f71096412f48bc76eaba7"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/YaI1GjtfVRH2kLVsjMQa4A--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTE1MDtjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/9425e1c34a8f71096412f48bc76eaba7","width":300,"height":107}},"lazy":false},{"type":"list","items":[{"val":[{"type":"text","content":"Four-year data show preservation of cardiac function, including LVEF","length":68,"tagName":"p"}]},{"val":[{"type":"text","content":"Skeletal muscle disease progression continues to slow with extended treatment (PUL v2.0)","length":88,"tagName":"p"}]},{"val":[{"type":"text","content":"Deramiocel’s long-term safety profile remains favorable","length":55,"tagName":"p"}]},{"val":[{"type":"text","content":"Results presented at PPMD’s 2025 Annual Conference","length":50,"tagName":"p"}]}],"tagName":"ul","bulletedList":true,"length":261,"olType":false},{"type":"text","content":"SAN DIEGO, June 20, 2025 (GLOBE NEWSWIRE) -- Capricor Therapeutics (NASDAQ: CAPR), a biotechnology company developing transformative cell and exosome-based therapeutics for rare diseases, today announced positive four-year safety and efficacy results from its ongoing HOPE-2 Open-Label Extension (OLE) study of Deramiocel, the Company’s lead cell therapy candidate for Duchenne Muscular Dystrophy (DMD). The data will be featured in the session titled “Therapies that Slow Progression” at the Parent Project Muscular Dystrophy (PPMD) 2025 Annual Conference, taking place June 21, 2025, in Las Vegas, Nevada.","length":607,"tagName":"p"},{"type":"text","content":"After four years of continuous treatment, Deramiocel-treated patients showed a median change of -0.5 points compared to baseline. Further, a subgroup analysis of patients with baseline LVEF >45% showed an even greater clinical benefit, supporting early intervention with Deramiocel to potentially preserve cardiac function.","length":326,"tagName":"p"},{"type":"text","content":"Additionally, treatment continued to slow skeletal muscle disease progression, as measured by Performance of the Upper Limb (PUL v2.0), with patients experiencing a smaller average ...

More updates from Capricor Therapeutics, Inc.

Duchenne Muscular Dystrophycardiac functionMuscular Dystrophyrare diseasesOLEBecker Muscular Dystrophysafety profileclinical trialsCapricorskeletal muscle