Business
Bruker Launches timsTOF fleX(TM) with ESI and MALDI for SpatialOMx(TM)
ATLANTA, May 31, 2019 /PRNewswire/ -- At the 67th American Society for Mass Spectrometry Conference (ASMS) being held June 2-6 in Atlanta, Bruker is
About this update from Bruker Corporation
[{"type":"text","content":"ATLANTA, May 31, 2019 /PRNewswire/ -- At the 67th American Society for Mass Spectrometry Conference (ASMS) being held June 2-6 in Atlanta, Bruker is announcing highly innovative new mass spectrometry products and workflows:\nA. SpatialOMx™ Life Sciences and Translational Mass Spectrometry Imaging \nBruker introduces the novel timsTOF fleX™ mass spectrometer, which includes a software-switchable MALDI source adapted to the ESI timsTOF Pro™ platform. This new, combined ESI/MALDI capability enables spatially-resolved omics, SpatialOMx™, on a single instrument. The timsTOF fleX comes with Bruker's proprietary 10kHz SmartBeam™ 3D laser with true pixel fidelity for rapid, label-free MALDI imaging at high-spatial resolution, while fully preserving the unparalleled 4D proteomics and phenomics sensitivity of the timsTOF Pro in ESI mode. \nWith this unique SpatialOMx approach, researchers gain insights into spatial molecular distributions in tissues from MALDI imaging, to guide 4D omics molecular expression studies, e.g. on proteins, low-level cancer antigen peptides, lipids, glycans, metabolites, or xenobiotics, which cannot be observed by traditional staining or labelling techniques. MALDI-guided SpatialOMx allows for specific targeting of cell sub-populations for subsequent ESI-TIMS/PASEF-based dda or dia 4D proteomics or 4D lipidomics/metabolomics. Both can now be performed on a single robust instrument, the timsTOF fleX, with the ultra-high sensitivity needed to advance single-cell biology research, as a perfect complement to single-cell transcriptomics by RNA-seq. \nProfessor Richard Drake, Director of the Proteomics Center at the Medical University of South Carolina, stated: \"The data from our samples using the new timsTOF fleX system was unprecedented in terms of spatial resolution and depth of glycan coverage. As glycans are emerging as potential clinical markers in tissue and serum to monitor overall immune status, and healthy or unhealthy aging, the unique capabilities of the timsTOF flex will greatly accelerate these efforts. The timsTOF flex allows our cumulative approaches that we have developed for tissue and biofluid analysis of cancers and immunotherapies to converge on one platform. I can see unlimited applications of such an instrument in many research areas for rapid glycan tissue imaging and biofluid 4D omics analysi...