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Bruker Introduces Novel 4D-Proteomics™ timsTOF® Capabilities
New AI-powered TIMSquant™ software for CCS-enabled, label-free quantification scalable to thousands of samples Early midia-PASEF® access for
About this update from Bruker Corporation
[{"type":"text","content":"\n\nNew AI-powered TIMSquant™ software for CCS-enabled, label-free quantification scalable to thousands of samples\n\n\n\nEarly midia-PASEF® access for immunopeptidomics and PTMs on ultra-sensitive timsTOF Ultra for DDA-like precursor traceability in dia-PASEF\n\n\n\nAffordable, high-throughput ~3,500 PG plasma proteomics on timsTOF HT with PreOmics ENRICH kit using Biognosys Spectronaut® 18 directDIA+™ software\n\n\n\nNew PepSep™ ULTRA XL and MAX HT nano-LC columns for DDA library creation and high-throughput proteomics, respectively \n\n\n\nNovel TwinScape™ digital twin for optimal timsTOF performance and uptime\n\n\n\nNew partnership with Mass Dynamics for biological knowledge generation\n\n\n\nEnhanced MALDI HiPLEX-IHC workflow for spatial tissue proteomics \n\n\n\nNew MetaboScape™ release for 4D-Lipidomics™ and 4D-Metabolomics™\n\n\n\n BUSAN, South Korea--(BUSINESS WIRE)--\nAt the 22nd Human Proteome Organization World Congress 2023, Bruker Corporation (Nasdaq: BRKR) today announced advances in instrumental methods, consumables and software for 4D-Proteomics, MALDI HiPLEX-IHC spatial tissue proteomics, 4D-Lipidomics and 4D-Metabolomics.\n\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230918138030/en/Fig. 1: TIMSquant for CCS-aware, AI-powered quantification (Graphic: Business Wire)\nA. Novel scalable AI-powered TIMSquant™ for label-free quantification\n\n\nBruker introduces TIMSquant a scalable, CCS-enabled AI-powered label-free quantification algorithm integrated into Bruker ProteoScape™. TIMSquant performs accurate quantification of peptides and proteins present in 100s or 1000s samples by using global retention time and collision cross-section (CCS) prediction models. Accurate, large-scale CCS data further increases specificity and quantification consistency based on previously identified peptides and aligned missing values.\n\n\nBruker ProteoScape is Bruker’s comprehensive GPU-powered, TIMS DIA-NN-based proteomics software optimized for CCS-centric informatics, and it now comes with the BPS Novor module for de novo peptide sequencing for immunopeptidomics. BPS Novor was co-developed with Rapid Novor Inc., a Canadian software and CRO company. TIMS DIA-NN is a customized version of highly regarded DIA-NN software by Demichev and collaborators.\n\n\nDr. Kosuke...