Business
Bruker Introduces Breakthrough MALDI-2 Source on timsTOF fleX, and Further Innovations in CCS-Enabled 4D Proteomics on timsTOF
MALDI-2 Increases Small Molecule Sensitivity by One or Two Orders of Magnitude New prm-PASEF Workflow for Translational 4D Proteomics Large-Scale,
About this update from Bruker Corporation
[{"type":"text","content":"\nMALDI-2 Increases Small Molecule Sensitivity by One or Two Orders of Magnitude\nNew prm-PASEF Workflow for Translational 4D Proteomics\nLarge-Scale, High-Precision Peptide CCS Measurements for Deep Learning\nShort-gradient dia-PASEF Methods for High Throughput 4D Proteomics\nUnique CCS-enabled Mobility Offset Mass Aligned (MOMA) for Identification of Isobars\n‘Run & Done’ Novel IP2/GPU Real-Time Search Engine for High-Throughput 4D Proteomics\n\n BILLERICA, Mass.--(BUSINESS WIRE)--\nAt the virtual ASMS 2020 Reboot conference, Bruker Corporation (Nasdaq: BRKR) today announces a major advance in matrix-assisted laser desorption ionization (MALDI) with the launch of the world’s first commercial MALDI-2 post-ionization (PI) source, which is now available as an option on the timsTOF fleX™ ESI/MALDI mass spectrometer. The novel MALDI-2 technology can offer one or two orders of magnitude higher sensitivity for many small molecules and lipids. MALDI-2 increases the applications range of MALDI mass spectrometry and imaging even further.\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200529005143/en/(Photo: Business Wire)\n\nMoreover, Bruker launches additional unique TIMS/PASEF-enabled 4D proteomics methods that leverage the large-scale, real-time availability of accurate collision cross sections (CCS) for tens of thousands of measured peptides per 4D nanoLC-CCS-MS/MS run. These new methods and software include prm-PASEF, short-gradient dia-PASEF, MOMA, and ‘Run and Done’ proteomics using a novel GPU-based real-time search engine. In addition to further enhanced peptide, protein and PTM identification, these CCS-enabled innovations allow for sustained, ultra-high sensitivity LFQ performance, and for truly high-throughput methods for 4D proteomics, 4D lipidomics and 4D metabolomics on the exceptionally robust timsTOF Pro platform.\n\n\nA. SpatialOMx® and Translational Mass Spectrometry Imaging on timsTOF fleX \n\n\nThe innovative MALDI-2 PI source increases both the sensitivity and range of applications of MALDI very significantly. MALDI-2 requires a second laser (266 nm) fired orthogonally into the expanding MALDI plume that is generated by Bruker’s proprietary primary SmartBeam™ 3D (355 nm) laser. An optimized flexMatrix™ formulation is recommended for MALDI-2. The new MAL...