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Bruker Announces Major Advances in CCS-Enabled 4D Proteomics at ASMS
Bruker PaSER™ software now incorporates transformative CCS-enabled DIA-NN deep neural network learning with breakthrough dia-PASEF capabilities to identify:
About this update from Bruker Corporation
[{"type":"text","content":"\n\nBruker PaSER™ software now incorporates transformative CCS-enabled DIA-NN deep neural network learning with breakthrough dia-PASEF capabilities to identify:\n\n\n>8000 quantified cell lysate proteins with 40-minute gradients\n\n\n>5000 quantified cell lysate proteins with 4.8-minute separations on Evosep One\n\n\n>5000 quantified proteins in just 10 ng of cell lysate digest with 95-minute gradients\n\n\n\n\nWork-in-progress CCS-enabled ‘prm Live’ on timsTOF Pro enables low-cost, targeted proteomics with >1800 peptides quantified with highest sensitivity and excellent CVs\n\n\nAdvances in CCS-enabled TIMScore™ algorithm yield significantly greater phosphopeptide and protein coverage with more confident peptide identifications\n\n\nNovel OligoQuest™ software and workflow for high confidence sequence verification in support of RNA and modified oligonucleotide therapeutics development\n\n\nSCiLS™ autopilot software for automated Mass Spectrometry Imaging (MSI) acquisition on the timsTOF fleX and rapifleX® MALDI platforms using Bruker IntelliSlides™\n\n\nShowcasing two novel systems launched already in June 2021:\n\n\ntimsTOF SCP for unbiased single cell proteomics (SCP), e.g., to study cell-type specific proteomes in spatial cancer biology and correlate them with sc-RNA-seq transcriptomes\n\n\nnext-generation timsTOF Pro 2 with unprecedented proteomic depth and throughput\n\n\n\n\n PHILADELPHIA--(BUSINESS WIRE)--\nAt the 69th ASMS meeting in Philadelphia, Bruker Corporation (Nasdaq: BRKR) announced novel CCS-enabled 4D proteomics for major capability enhancements for timsTOF Pro 2, timsTOF fleX and timsTOF SCP mass spectrometers.\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211102005437/en/Graphical representation of dia-PASEF scan function (Graphic: Business Wire)\nDr. Rohan Thakur, Bruker’s EVP for Life Sciences Mass Spectrometry explained: “TIMScore developed by the Yates Lab at Scripps reduces peptide candidate ambiguity by evaluating predicted against experimental CCS, for forward and decoy/reverse peptides. The utility of CCS values augments DIA-NN in our collaboration with the Ralser Lab at Charité, and it also enhances the detection of PhoX™ crosslinked peptides in our collaboration with the Scheltema Lab at Utrecht University. Finally, the Marto Lab at Dan...