Business
Bruker Announces Introduction of Revolutionary d-DNP Polarizer for MRI Research and for Dynamic Nuclear Polarization Liquids NMR
First successful customer installation of novel dissolution d-DNP Polarizer at UCSF SAN FRANCISCO--(BUSINESS WIRE)-- Bruker Corporation today announced the
About this update from Bruker Corporation
[{"type":"text","content":"\nFirst successful customer installation of novel dissolution d-DNP Polarizer at UCSF\n\n SAN FRANCISCO--(BUSINESS WIRE)--\nBruker Corporation today announced the introduction of its groundbreaking dissolution Dynamic Nuclear Polarization (d-DNP) Polarizer at the 2025 Hyperpolarized Carbon-13 MRI Technology Development Workshop at the University of California San Francisco (UCSF) Hyperpolarized MRI Technology Resource Center. The first customer installation of this innovative technology has been successfully completed, marking a milestone in hyperpolarized MRI for preclinical research to improve cancer diagnostics and to assess response to treatment.\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250402925205/en/Bruker d-DNP polarizer shown (center) at UCSF, between Bruker 9.4T MRI (far left) and Fourier 80 NMR (right of polarizer). The novel d-DNP system enables >10,000x signal gains on 13C in high-field MRI and NMR systems.\nDynamic Nuclear Polarization (DNP) can enhance the sensitivity of Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) by transferring polarization from electron spins to nuclear spins. Dissolution DNP (d-DNP) extends the applicability of DNP to solution-state liquids NMR and to preclinical MRI research. Polarization occurs in a separate 7 Tesla polarizer magnet at temperatures below 1.4 Kelvin, accelerated by Bruker’s proprietary active cross-polarization technology.\n\nSubsequently, the highly polarized frozen sample is ejected, melts and dissolves, achieving sensitivity gains of over 10,000-fold in solution samples near room or body temperatures, enabling the observation of low-abundance nuclei like 13C in real-time. Hyperpolarized MRI using d-DNP is particularly beneficial for in vivo studies of 13C-labelled metabolites, enabling live tracking of chemical conversion to downstream metabolites. This highlights metabolic differences between healthy and diseased tissues for conditions ranging from cancer to cardiac health. It can be used to assess response to treatment in animal models, contributing to understanding drug efficacy and disease mechanisms.\n\nWith the novel Bruker d-DNP Polarizer, scientists can conduct previously impossible experiments in chemical or metabolic analysis in NMR and preclinical MRI. Bruker provides ...