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Bolt Biotherapeutics Enrolls First Patient in Phase 2 Clinical Study Evaluating BDC-1001 in Patients with HER2-Positive Breast Cancer Previously Treated with Enhertu®
BDC-1001 is a Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) in Phase 2 development for HER2-positive breast, colorectal, endometrial, and
About this update from Bolt Biotherapeutics, Inc.
[{"type":"text","content":"BDC-1001 is a Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) in Phase 2 development for HER2-positive breast, colorectal, endometrial, and gastroesophageal cancersPoster detailing trial design and rationale to be presented at the 2023 San Antonio Breast Cancer Symposium on Wednesday, December 6 REDWOOD CITY, Calif., Dec. 05, 2023 (GLOBE NEWSWIRE) -- Bolt Biotherapeutics, Inc. (Nasdaq: BOLT), a clinical-stage biopharmaceutical company developing novel immunotherapies for the treatment of cancer, today announced that the first patient has been dosed in the Phase 2 clinical trial investigating BDC-1001, a HER2-targeting Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC), as a single agent and in combination with the HER2-targeting antibody pertuzumab. The first patient was treated at City of Hope, one of the largest cancer research and treatment organizations in the United States, by Irene Kang, M.D., Medical Director, Women’s Health Medical Oncology, and Assistant Professor, Department of Medical Oncology and Therapeutics Research at City of Hope’s cancer center in Irvine, California. “The dosing of the first patient in this trial is a significant achievement in our efforts to find new treatment options for patients with HER2-positive breast cancer that continues to progress after treatment,” said Kang, a principal investigator on the study. “Despite the numerous HER2-targeted therapeutics approved for treating advanced or metastatic HER2-positive breast cancer, many patients ultimately have disease progression and new options for treating these individuals are urgently needed.” The addition of pertuzumab has been shown to improve anti-tumor efficacy in preclinical models. The trial will treat patients with HER2-positive metastatic breast cancer previously treated with trastuzumab deruxtecan (Enhertu®). “Patients with HER2-positive breast cancer who progress after Enhertu have few therapeutic options,” said Edith A. Perez, M.D., Chief Medical Officer of Bolt Biotherapeutics. “BDC-1001 has a unique mechanism of action compared to available agents, mobilizing the patient’s immune system to fight cancer. This provides scientific and clinical rationale for this new study. This is also our first opportunity to clinically validate the compelling anti-tumor activity we saw preclinically when combining BDC-1001 surrogate with ...