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Black Diamond Therapeutics to Present Pre-Clinical Data on BDTX-189 and BDTX-1535 at American Association for Cancer Research Annual Meeting
CAMBRIDGE, Mass. and NEW YORK, March 10, 2021 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company
About this update from Black Diamond Therapeutics, Inc.
[{"type":"text","content":"CAMBRIDGE, Mass. and NEW YORK, March 10, 2021 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies, today announced that pre-clinical data on BDTX-189 and BDTX-1535 will be presented as late-breaking poster presentations at the American Association for Cancer Research (AACR) Virtual Annual Meeting, taking place April 10-15, 2021. Presentation details are as follows: Title: Prospective pre-clinical modeling to estimate clinical pharmacokinetics and doses of BDTX-189, an inhibitor of allosteric ErbB mutations in advanced solid malignancies Session Type: E-Poster Session Session Category: Experimental and Molecular TherapeuticsSession Title: Pharmacology, Pharmacogenetics, and PharmacogenomicsDate and Time: Saturday, April 10, 8:30 AM ETAbstract Number: LB127 Title: CNS penetrant, irreversible inhibitors potently inhibit the family of allosteric oncogenic EGFR mutants expressed in GBM and demonstrate efficacy in patient-derived xenograft models Session Type: E-Poster Session Session Category: Experimental and Molecular TherapeuticsSession Title: Tyrosine Kinase and Phosphatase Inhibitors Date and Time: Saturday, April 10, 8:30 AM ETAbstract Number: LB140 Full abstracts will be published online at 12:01 AM ET on April 9, 2021 on the AACR website at www.aacr.org. Both presentations will also be available online on the Company’s website at https://www.blackdiamondtherapeutics.com/technology/presentations-publications/. About BDTX-189BDTX-189 is an orally available, irreversible small molecule inhibitor that blocks the function of an undrugged family of oncogenic proteins defined by driver mutations across a range of tumor types, and which affect both of the epidermal growth factor receptor (EGFR) and the tyrosine-protein kinase, ErbB-2, or human epidermal growth factor receptor 2 (HER2). These mutations include extracellular domain allosteric mutations of HER2, as well as EGFR and HER2 kinase domain exon 20 insertions, and additional activating oncogenic drivers of ErbB. The ErbB receptors are a group of receptor tyrosine kinases involved in key cellular functions, including cell growth and survival. BDTX-189 is also designed to spare normal, or wild type EGFR, which we believe will improve upon th...