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Black Diamond Therapeutics Presents Preclinical Data on BDTX-1535 and BDTX-4933 at the 34th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
BDTX-1535 is an irreversible MasterKey inhibitor of multiple EGFR alterations that utilize similar activated oncogenic EGFR conformations to drive tumor cell
About this update from Black Diamond Therapeutics, Inc.
[{"type":"text","content":"BDTX-1535 is an irreversible MasterKey inhibitor of multiple EGFR alterations that utilize similar activated oncogenic EGFR conformations to drive tumor cell growth in GBM and NSCLC BDTX-1535 demonstrated potent systemic and CNS anti-tumor activity and survival benefit in multiple PDX models of GBM and NSCLC tumors driven by a family of EGFR alterations, including resistance mutations and EGFR amplification BDTX-4933 is a MasterKey inhibitor of oncogenic isoforms of the RAF family, which demonstrated on-target cell growth inhibition in vitro and tumor growth regression in in vivo tumor models driven by oncogenic Class I, II and III BRAF alterations and NRAS mutations CAMBRIDGE, Mass. and NEW YORK, Oct. 26, 2022 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of MasterKey therapies, today announced the presentation of three posters reporting new preclinical data on BDTX-1535 and BDTX-4933 at the 34th European Organisation for Research and Treatment of Cancer—National Cancer Institute—American Association for Cancer Research (EORTC-NCI-AACR) Symposium on Molecular Targets and Cancer Therapeutics being held in Barcelona, Spain. The poster presentations highlight new preclinical data demonstrating robust anti-tumor activity of both programs in a broad range of preclinical models of oncogene driven cancers. “Despite the recent advancements in next generation sequencing to allow for tailored oncology therapeutics, less than 15% of metastatic cancer patients are eligible for approved precision oncology medicines. We believe our ability to characterize potentially oncogenic mutations, de-orphan them, and group our targets into druggable oncogene families provides a promising and next-generation approach to precision oncology drug development,” said Elizabeth Buck, Ph.D., Chief Scientific Officer of Black Diamond Therapeutics. “These preclinical results demonstrate key features of our epidermal growth factor receptor (EGFR) MasterKey inhibitor BDTX-1535, including its ability to irreversibly inhibit a family of EGFR driver mutations expressed in both lung and brain cancers while sparing wild type (WT) EGFR, its brain penetrance profile, and its ability to promote tumor regression across a full range of EGFR-driven tumor models representing...