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Black Diamond Therapeutics Announces Upcoming Presentation at AACR Annual Meeting 2024
Abstract accepted for oral presentation on the evolving EGFR mutational landscape in NSCLC and MasterKey profile of BDTX-1535 addressing a broad spectrum of
About this update from Black Diamond Therapeutics, Inc.
[{"type":"text","content":"Abstract accepted for oral presentation on the evolving EGFR mutational landscape in NSCLC and MasterKey profile of BDTX-1535 addressing a broad spectrum of mutations\nCAMBRIDGE, Mass., March 05, 2024 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a clinical-stage oncology company developing MasterKey therapies that target families of oncogenic mutations in patients with cancer, today announced an upcoming oral presentation at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place April 5-10 in San Diego, California. The presentation will describe real world data of the evolving EGFR mutation landscape in patients with NSCLC, highlighting the increasing relevance of “non-classical” EGFR mutations, which can be found in up to 30% of EGFRm NSCLC. The presentation will also describe the profile of BDTX-1535, an oral, brain-penetrant MasterKey inhibitor that selectively targets more than 50 oncogenic EGFR mutations. Abstract Number: 1229Title: BDTX-1535 – A MasterKey EGFR Inhibitor Targeting Classical, Non-Classical and the C797S Resistance Mutation to Address the Evolved Landscape of EGFR Mutant NSCLCSession Title: MinisymposiaSession Date and Time: Sunday, April 7, 2024, 3:00-5:00pm PDT Location: San Diego Convention Center About BDTX-1535BDTX-1535 is an oral, brain-penetrant MasterKey inhibitor of oncogenic epidermal growth factor receptor (EGFR) mutation in non-small cell lung cancer (NSCLC), including classical driver mutations, families of non-classical driver mutations (e.g., L747P, L718Q), acquired resistance C797S mutation, and complex mutations. BDTX-1535 is a fourth-generation tyrosine kinase inhibitor (TKI) that potently inhibits, based on preclinical data, more than 50 oncogenic EGFR mutations expressed across a diverse group of patients with NSCLC in multiple lines of therapy. Based on preclinical data, BDTX-1535 also inhibits EGFR extracellular domain mutations and alterations commonly expressed in glioblastoma (GBM) and avoids paradoxical activation observed with earlier generation reversible TKIs. A “window of opportunity” trial of BDTX-1535 in patients with GBM is ongoing (NCT06072586) and a Phase 2 trial is currently ongoing in patients with NSCLC (NCT05256290). About Black Diamond TherapeuticsBlack Diamond Therapeutics is a clinical-stage oncology company focus...