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Black Diamond Therapeutics Announces Pre-Clinical Data Presentations on New Programs Targeting BRAF and FGFR at ESMO TAT Virtual Congress 2021
CAMBRIDGE, Mass. and NEW YORK, March 02, 2021 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company
About this update from Black Diamond Therapeutics, Inc.
[{"type":"text","content":"CAMBRIDGE, Mass. and NEW YORK, March 02, 2021 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies, today announced the presentation of pre-clinical data from two programs emerging from the Company’s proprietary MAP platform targeting BRAF and fibroblast growth factor receptor (FGFR) at the European Society of Medical Oncology Targeted Anticancer Therapies (ESMO TAT) Virtual Congress 2021, taking place March 1-2, 2021. “BRAF and FGFR are validated oncogenes, yet current standards of care have meaningful limitations giving rise to substantial unmet need for cancer patients,” said Chris Roberts, Ph.D., Chief Scientific Officer of Black Diamond Therapeutics. “In contrast, our BRAF and FGFR program compounds are designed to be potent MasterKey inhibitors of spectrums of previously uncharacterized allosteric oncogenic driver mutations that were identified and validated by our proprietary MAP platform.” Dr. Roberts continued, “Our programs aim to address specific deficiencies associated with current-generation therapies. Our BRAF program compounds are designed to target the full spectrum of BRAF oncogenic mutations and avoid paradoxical activation, which leads to secondary malignancies. Our FGFR compounds are designed to target the full spectrum of oncogenic FGFR2 and FGFR3 mutations while sparing FGFR1 and retaining activity against gatekeeper mutations, supporting the potential capture of efficacy otherwise left on the table. Collectively, these pre-clinical data support the potential of both programs to generate differentiated product candidates for patients.” The presentations describe the following data: BRAF Program:The presentation describes pre-clinical data for Black Diamond’s BRAF program candidates, which are designed for potency against a spectrum of non-canonical Class II/III (non-V600) mutations, as well as to avoid induction of paradoxical activation. BRAF program candidates potently inhibit the proliferation of Ba/F3 transformants expressing a broad spectrum of non-canonical, dimer-promoting Class II/III mutations.Current-generation BRAF therapies often induce paradoxical activation that can lead to secondary malignancies. In contrast, treatment of cells harboring WT-BRAF with Black...