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Bionano Genomics Announces Release of Version 6.2 of its NxClinical Software with Significant New Capabilities for Cancer Research Applications Including HRD Analysis
Version includes a powerful capability for genomic scar analysis for assessments of homologous recombination deficiency (HRD) that provides an efficient,
About this update from Bionano Genomics, Inc.
[{"type":"text","content":"Version includes a powerful capability for genomic scar analysis for assessments of homologous recombination deficiency (HRD) that provides an efficient, consistent approach for analysis of tumor biomarkers used in pharmacogenomics and other cancer research\nSAN DIEGO, April 07, 2022 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (BNGO), pioneer of optical genome mapping (OGM) solutions on the Saphyr® system and provider of NxClinical™ software, the leading solution for visualization, interpretation and reporting of genomic data, today announced the launch of an integrated genomic scar analysis for homologous recombination deficiency (HRD) in the version 6.2 software release of NxClinical. This feature provides a comprehensive, consistent, and automated analysis of biomarkers from next-generation sequencing (NGS) and microarray data that can help clinical researchers stratify therapeutic response across multiple tumor types. Integrated HRD genomic scarring has been introduced into this latest version of NxClinical software, developed by BioDiscovery, to measure genomic instability in a platform-agnostic way. This analysis allows cancer researchers to gain important insights from genetic data they are already generating from widely available array and sequencing assays, including several from Illumina, ThermoFisher, and Agilent. HRD represents a disruption to the normal cellular pathway that repairs double-stranded DNA breaks, which consequentially results in acquired chromosomal breakage. Clinical research has shown that cells with HRD are more sensitive to certain therapies, like Poly(ADP-Ribose) Polymerase (PARP) inhibitors and other DNA repair-targeting drugs; therefore, a measurement of HRD may be an effective pharmacogenetic biomarker across various tumor types. NxClinical software includes measurement of three genomic scars – Loss of Heterozygosity (LOH), Telomeric Allelic Imbalance (TAI), and Large-Scale State Transitions (LST) – that signal large-scale genomic instability. The automation of genomic scar analysis can simplify and expand access to HRD status assessment of cancer samples and enhance the clarity and transparency of tumor profiles. This analysis has the potential to drive improved stratification for clinical trials and provide pharmacogenomic-driven decisions in a precise manner that is relevant to the underlying...