Bionano Genomics Announces Publication of Landmark Research Study in Myelodysplastic Syndrome Showing OGM Data would Result in Revised Prognostic Risk Classification or Additional Actionable Variants in 28% of Study Participants

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[{"type":"text","content":"SAN DIEGO, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today announced the publication of the first study to evaluate the utility of optical genome mapping (OGM) for myelodysplastic syndrome (MDS) prognostication. In the peer-reviewed study, published in Leukemia, researchers from The University of Texas MD Anderson Cancer Center reported that when OGM was used instead of karyotyping, 17 to 21% of study subjects had different prognostic risk scores and in 13% of study subjects additional pathogenic variants were revealed. The OGM results were also compared to results of a next-generation sequencing (NGS) panel used for molecular pathology. The comparison to NGS showed that the utility of OGM above and beyond that of karyotyping is not provided by NGS. Corresponding author, Dr. Rashmi Kanagal-Shamanna, from MD Anderson commented, “The results of this study demonstrate that we are grossly under-evaluating the degree of genomic aberrations. Most patients with high-risk MDS are not responsive to available therapies, pointing to the urgent need for new therapeutic alternatives that will improve the clinical outcomes of these patients and better tools to help in that pursuit. This study underscores the potential for OGM to become a single-platform cytogenetic tool for structural variant profiling in indications such as MDS, and shows that when OGM and NGS are combined, the success rate of finding pathogenic variants is higher than with any traditional methods in use today.\" The study analyzed 101 consecutive, newly diagnosed MDS patients from a single center within MD Anderson. Multiple analysis methods, including OGM, karyotyping, fluorescence in situ hybridization (FISH), chromosomal microarray analysis (CMA) and an 81-gene NGS panel were used to detect pathogenic structural variants (SVs) and single nucleotide variants (SNVs) in the samples. The findings showed that OGM detected nearly twice the number of pathogenic SVs compared to traditional cytogenetic methods. When the OGM results were used to calculate prognostic risk scores by the comprehensive cytogenetic scoring system (CCSS), the risk scores were different for 21% of study subjects and when the international prognostic scoring system (IPSS) was used, the risk scores were different for 17% of study subjects. Prognostic risk is a component of dis...

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