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Bionano Genomics Announces a Publication From the First Affiliated Hospital of Zhengzhou Highlighting the Utility of OGM
SAN DIEGO, May 12, 2022 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO), pioneer of optical genome mapping (OGM) solutions on the Saphyr® system and
About this update from Bionano Genomics, Inc.
[{"type":"text","content":"SAN DIEGO, May 12, 2022 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO), pioneer of optical genome mapping (OGM) solutions on the Saphyr® system and provider of NxClinical™ software, the leading solution for visualization, interpretation and reporting of genomic data, today announced the publication of an evaluation of OGM from The First Affiliated Hospital of Zhengzhou, the largest hospital in Central China, highlighting the utility of OGM for structural variant analysis, including in a workflow for preimplantation genetic testing. In this study, researchers, led by Dr. Xiangdong Kong, evaluated the use of OGM to detect chromosome balanced translocations and compared results to a variety of methods, including karyotype analysis, FISH, and CNV-seq. Balanced reciprocal translocations are one of the most common chromosomal abnormalities and may lead to infertility, recurrent pregnancy loss, or genetic defects. Analysis of this abnormality may be helpful in the screening and analysis of embryos prior to implantation, as part of fertility treatment. The paper suggests a need for new methods to complement existing analysis techniques, such as karyotype and FISH, which are described as time consuming and relatively low-resolution, and next generation sequencing (NGS) which can enable copy number variation (CNV) analyses at the whole genome level but cannot be used to detect chromosomal translocations or inversions. The authors demonstrated that OGM performed well in the analysis of these variants, which led them to suggest that OGM could be used as part of the workflow to detect chromosomal abnormalities at a higher resolution. “We believe this paper highlights the growing validation of OGM in different applications for clinical research in cytogenetics. The work by Dr. Kong and his team at Zhengzhou University further extends this validation and highlights the utility of OGM. Incorporating OGM data in the analysis of embryos prior to implantation is innovative and the approach could be part of a solution for recurrent pregnancy loss, which represents an area of unmet need globally,” commented Erik Holmlin, PhD, president and chief executive officer of Bionano Genomics. The paper is available at: Evaluation of optical genome mapping for detecting chromosomal translocation in clinical cytogenetics - Dai - - Molecular Genetics...