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Bionano Announces Use of OGM in Preimplantation Genetic Testing as Part of Successful Live Birth to a Couple Experiencing Recurrent Pregnancy Loss
OGM uniquely identified a complex chromosomal rearrangement missed by classical cytogenetics, helping clinical researchers apply targeted screening to select
About this update from Bionano Genomics, Inc.
[{"type":"text","content":"OGM uniquely identified a complex chromosomal rearrangement missed by classical cytogenetics, helping clinical researchers apply targeted screening to select the most fit embryos for transferFollowing in-vitro fertilization, preimplantation genetic testing and selection of fit embryos, a healthy baby was born to a couple that had previously experienced years of recurrent pregnancy loss SAN DIEGO, Jan. 14, 2025 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today announced publication of a case study from the Shenzhen Maternity and Child Healthcare Hospital, China, demonstrating the application of optical genome mapping (OGM) in a protocol for preimplantation genetic testing for structural rearrangements (PGT-SR). In-vitro fertilization (IVF) and the PGT-SR protocol, which included OGM, led to selection of the presumed most viable embryos, resulting in a viable pregnancy and the birth of a healthy baby to a couple experiencing years of recurrent pregnancy loss (RPL). The couple had experienced years of RPL due, presumably, to complex chromosomal rearrangements (CCRs) identified in the male partner. OGM revealed previously undetected CCRs in the male that traditional cytogenetic methods had missed. The OGM findings helped to inform embryo selection to identify and transfer the presumed most viable embryo, which resulted in pregnancy. Prenatal testing during the pregnancy confirmed a normal karyotype, and the pregnancy went to full term and live birth with the couple welcoming a healthy baby. Erik Holmlin, president and chief executive officer of Bionano commented, “This case study suggests that OGM could play a role in helping people experiencing infertility or RPL achieve their dreams of parenthood. RPL affects millions of people worldwide and infertility affects 1 in 6 couples, so this research could be a significant breakthrough. We couldn’t be prouder to have OGM be a part of this successful pregnancy and healthy live birth.” The full research publication is available at: A healthy live birth after preimplantation genetic testing for structural rearrangements and Bionano revealed exceptionally complex chromosome rearrangements. About Bionano Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s m...