Bionano Announces Commercial Release of New Kits for its Ionic System featuring New Chemistry for Nucleic Acid Extraction from FFPE and Tumor Tissue

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[{"type":"text","content":"SAN DIEGO, June 06, 2023 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today announced the commercial release of new kits for its Ionic® Purification System featuring new chemistry for nucleic acid extraction from formalin-fixed paraffin-embedded (FFPE) and tumor tissue. These products offer potential improvements in quality and yield of nucleic acid extracted from complex biological samples including those with low cell counts or otherwise challenging sample types, such as FFPE tumor samples. Most clinical samples used in oncology research are stored as FFPE tissues, which often contain degraded or fragmented nucleic acid. Conventional extraction methods are labor intensive and can further damage nucleic acid during the extraction and purification process. The Ionic Purification System uses isotachophoresis (ITP) to extract, purify and concentrate nucleic acid from biological samples without binding, washing, or stripping from fixed surfaces. Since nucleic acids remain in their native form when using the ITP workflow on the Ionic system, it can be an ideal solution for many sample types, including limited and low-quality solid tumor and homologous recombination deficiency (HRD) samples. The Ionic® G2 chemistry includes four new kits for use with the Ionic Purification System, including G2 FFPE to DNA, G2 FFPE to RNA, G2 FFPE Complete and G2 Tissue to DNA. Ionic G2 kits enable ITP to provide up to a potential 4.5-fold increase in nucleic acid yield over the leading column-based system, with higher quality sample results and reduced sample processing time. ITP on the Ionic system is currently focused on nucleic acid purification for applications with next-generation sequencing (NGS). Bionano is developing ITP solutions for optical genome mapping (OGM) that are planned to be available in the future. “Bionano acquired Purigen so we could develop an ITP workflow for ultra-high molecular weight (UHMW) DNA. We’re continuing to support applications of ITP on the Ionic system in other areas, especially for NGS, because we believe it provides us a bridge to the molecular pathology community independent of OGM,” said Erik Holmlin, PhD, president and chief executive officer of Bionano. More information on the Ionic system can be found here. About Bionano Bionano is a provider of genome analysis solutions that can enable researc...

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