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Biomea Fusion to Present Preclinical Data for BMF-500, an Investigational Oral Covalent FLT3 Inhibitor, at the 64th American Society of Hematology (ASH) Annual Meeting
BMF-500, an investigational third generation covalent FLT3 inhibitor, has demonstrated preclinically that it may be the most potent and selective inhibitor of
About this update from Biomea Fusion, Inc.
[{"type":"text","content":"BMF-500, an investigational third generation covalent FLT3 inhibitor, has demonstrated preclinically that it may be the most potent and selective inhibitor of FLT3 evaluated to date: Greater Cytotoxicity: In acute myeloid leukemia (AML) cell lines, three-hour treatment with BMF-500 followed by washout produced higher cell killing at 96 hours than continuous exposure to the non-covalent FLT3 inhibitor gilteritinibSustained FLT3 Inhibition: BMF-500 elicited complete tumor regression of FLT3-ITD in mouse tumor models and maintained its effect without continued exposureHighly Selective: Kinase panel assay displayed potential best in class selectivity towards FLT3FLT3 mutant efficacy profile displayed significant benefit over existing FLT3 inhibitors Approximately one third of patients diagnosed with AML have a FLT3 mutation, which is associated with poor outcomesBiomea Fusion remains on track to file an IND for BMF-500 in the first half of 2023 REDWOOD CITY, Calif., Nov. 03, 2022 (GLOBE NEWSWIRE) -- Biomea Fusion, Inc. (Nasdaq: BMEA), a clinical-stage biopharmaceutical company dedicated to discovering and developing novel covalent small molecules to treat and improve the lives of patients with genetically defined cancers and metabolic diseases, today announced it will present preclinical data of investigational covalent FLT3 inhibitor, BMF-500, at the 64th ASH Annual Meeting, which will be held from December 10-13, 2022, at the Ernest N. Morial Convention Center in New Orleans, Louisiana. BMF-500 was discovered and developed in-house at Biomea using the company’s proprietary FUSION™ System and designed to have a therapeutic profile to allow for combinations with standard of care and/or novel targeted agents like BMF-219, Biomea’s investigational covalent menin inhibitor. The company is on track to submit an investigational new drug (IND) application for BMF-500 in the first half of 2023 and, subject to the successful clearance of an investigational new drug (IND) application, plans to initiate clinical trials evaluating BMF-500 as a single agent and in novel combinations. “We believe the preclinical data we will present at ASH has the potential to establish BMF-500 as the most potent and selective FLT3 inhibitor reported to date. BMF-500’s unique profile and robust preclinical data demonstrate our growing expertise in developing nex...