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Biodesix Announces Publication Highlighting Interim Data from the INSIGHT Study Assessing the Clinical Effectiveness of VeriStrat® Proteomic Test in the Journal of Immunotherapy of Cancer
Data published shows the VeriStrat proteomic test improved overall patient survival by better informing physicians on the selection of immunotherapies to
About this update from Biodesix, Inc.
[{"type":"text","content":"\nData published shows the VeriStrat proteomic test improved overall patient survival by better informing physicians on the selection of immunotherapies to optimally treat NSCLC patients\n\n BOULDER, Colo.--(BUSINESS WIRE)--\nBiodesix, Inc. (Nasdaq: BDSX), a leading data-driven diagnostic solutions company with a focus in lung disease, announced new interim data published from the large multi-center observational registry study INSIGHT (Clinical Effectiveness Assessment of VeriStrat® Testing and Validation of Immunotherapy Tests in NSCLC Subjects) (NCT03289780) utilizing its novel predictive and prognostic blood-based host immune classifier (the VeriStrat test) to stratify Immune checkpoint inhibition (ICI) treatment response in patients with advanced non-small cell lung cancer(NSCLC). The study, titled “Real-world performance of blood-based proteomic profiling in first-line immunotherapy treatment in advanced stage non-small cell lung cancer,” was published in the Journal of Immunotherapy of Cancer (JITC) and can be viewed here.\n\nResults from the prespecified INSIGHT interim analysis of approximately 2,000 patients with at least one year of follow up showed that patients classified by VeriStrat as host immune classifier hot (HIC-Hot) had better outcomes, on average living 2-3 times longer when compared to patients classified by VeriStrat as HIC-Cold. A classification of HIC-H, also known as VeriStrat Good, implies that the normal tumor-directed immunity is active and patients are potentially responsive to therapies that boost immune response. HIC “cold” classification, also known as VeriStrat Poor, correlates to what experts refer to as an “immune desert,” where tumor-directed immunity is compromised. Results additionally suggest that HIC-C (Veristrat Poor) patients should not be treated with single-agent ICI therapy regardless of their PD-L1 expressions.\n\n“Inflammatory biomarker-driven treatment selection of immunotherapy in lung cancer may further improve upon the already astounding results noted with immunotherapy,” said Wallace Akerley, M.D., of Huntsman Cancer Institute. “Further, observational studies, like INSIGHT, offer physicians valuable information gleaned from the broader population when determining optimal treatment approaches for their patients with NSCLC.”\n\nICI either single agent or in combination with che...