Business
BioAtla Presented Phase 2 Clinical Trial Data at the IASLC 2023 North America Conference on Lung Cancer and Virtual KOL Event
Results from the Phase 2 BA3011 clinical non-small cell lung cancer (NSCLC) study demonstrated promising clinical benefits in heavily pre-treated non-squamous
About this update from Bioatla, Inc.
[{"type":"text","content":"Results from the Phase 2 BA3011 clinical non-small cell lung cancer (NSCLC) study demonstrated promising clinical benefits in heavily pre-treated non-squamous histology patients across key endpoints BA3011 is a CAB-AXL antibody-drug conjugate (ADC) being studied in refractory NSCLC patients SAN DIEGO, Dec. 05, 2023 (GLOBE NEWSWIRE) -- BioAtla, Inc. (Nasdaq: BCAB), a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics for the treatment of solid tumors, presented a poster and discussion entitled “Phase 2 Trial of Mecbotamab Vedotin (BA3011), a CAB-AXL-ADC, Alone or in Combination with Nivolumab in Patients with Non-Squamous NSCLC” at the IASLC Conference December 1–3 and at a virtual KOL Event held December 4, 2023. “Patients with AXL-positive treatment-refractory NSCLC have an unusually poor prognosis, few treatment options, and we don’t typically see clinical benefit in these patients,” said Dr. Gay, MD, PhD, Assistant Professor, Department of Thoracic-Head & Neck Medical Oncology at MD Anderson Cancer Center. “Observing promising antitumor activity, including mulltiple partial responses (PRs) and over 4 months duration of response, following BA3011 is particularly exciting and a significant achievement in heavily pre-treated refractory patients.” “The results from the Phase 2 trial in NSCLC continue to show the potential of BA3011 in refractory NSCLC,” said Jay M. Short, Ph.D., Chairman, Chief Executive Officer and co-founder of BioAtla, Inc. “Our recent regulatory feedback as well as the benefit-risk profile we have observed to date with our 1.8 mg/kg Q2W BA3011 dosing regimen support advancing this dose in a potentially registrational study. Furthermore, the meaningful antitumor activity among patients with AXL expression of only 1% supports the development of BA3011 in target agnostic populations. Taken together, we believe BioAtla has a significant commercial opportunity to access a larger market and treat more patients with our CAB-AXL-ADC asset.” Data highlights from the poster presentation and KOL event include: In the BA3011 monotherapy arm (n = 23), 1.8 mg/kg BA3011 Q2W showed encouraging efficacy signals: AXL-positive patients were enrolled and had received a median of at least 3 prior lines of therapyPatients who previously experienced PD...