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Bio-Techne And NanoString Announce Offering Of RNAscope Reagents Validated For Use With The GeoMx Digital Spatial Profiler
Curated Menu of Off-the-Shelf RNAscope Probes Provide Molecularly-Guided Region of Interest Selection for Use with the New NGS-Enabled Cancer Transcriptome
About this update from Bio-techne Corp
[{"type":"text","content":"Curated Menu of Off-the-Shelf RNAscope Probes Provide Molecularly-Guided Region of Interest Selection for Use with the New NGS-Enabled Cancer Transcriptome Atlas\n\n\nMINNEAPOLIS and SEATTLE, Aug. 6, 2020 /PRNewswire/ -- Bio-Techne (NASDAQ:TECH), a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic markets and NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today announced an expansion of their partnership to include compatibility with ACD's 21,000+ RNAscope probes and 10 qualified RNAscope probe combinations with GeoMx® Digital Spatial Profiler (DSP) and the recently launched GeoMx Cancer Transcriptome Atlas (CTA).\n\n \n \n \n \n \n \n\n \nA combined workflow has been previously developed that unites the RNAscope reagent portfolio from Bio-Techne with NanoString's GeoMx RNA Assays to enable researchers to visualize RNA in tissue at the single molecule level to molecularly guide their high-plex spatial analyses on GeoMx DSP. Users can select any RNAscope probe to visualize their FFPE or fresh frozen tissue morphology as an alternative to antibody-based visualization. The full tissue image generated by RNAscope probes is used as a region of interest (ROI) selection on GeoMx DSP for high-plex profiling. Ten new 2- or 3-plex qualified RNAscope probe combinations take this workflow one step further, providing pre-qualified RNAscope reagents for use in the joint workflow to ensure cross assay compatibility. Selected combinations cover key applications in immuno-oncology, including targets difficult to detect with traditional antibodies, such as chemokines, cytokines, immune checkpoints, and key immune cell types. \n\"One of the top applications of RNAscope is immuno-oncology, which is demonstrated by our large number of top tier publications in this field. Spatial Genomics is enabling key research, broadening our understanding of disease mechanisms and pathology and we are proud to expand its utility through our continued partnership with NanoString,\" said Kim Kelderman, President Diagnostics and Genomics Segment, Bio-Techne.\n\"This next step in our partnership pairs the best of RNAscope's immuno-oncology imaging content with the comprehensive profiling coverage of the cancer transcri...