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Bio-Techne Advances Spatial Biology Solutions Bridging Translational Research to Clinical Applications
RNAscope™ technology and the Lunaphore COMET™ enable simultaneous RNA and protein detection on the same tissue sectionTechnologies support spatial multiomic
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[{"type":"text","content":"RNAscope™ technology and the Lunaphore COMET™ enable simultaneous RNA and protein detection on the same tissue sectionTechnologies support spatial multiomic analysis and deeper insights for pathology workflowsResearch highlights potential role in clinical utility workflows for lymphoid malignancies and B-cell clonalityMINNEAPOLIS, Sept. 26, 2025 /PRNewswire/ -- Bio-Techne Corporation (NASDAQ: TECH), a global provider of life science tools, reagents and diagnostic products, today announced new advancements in its spatial biology portfolio for the RNAscope™ ISH technology and the Lunaphore COMET™. These solutions help researchers and pathologists bridge the gap between translational research and clinical applications by enabling the detection of RNA and protein biomarkers on the same tissue section.\nRNAscope™ empowers pathologists and histologists to detect clinically relevant biomarkers—such as viral markers, secreted proteins, point mutations, and chromosomal translocations—within routine anatomic pathology workflows. COMET™ offers fully automated, high-throughput hyperplex analysis of both RNA and protein biomarkers, accelerating spatial multiomic workflows and enabling deeper biological insights.\nScientific investigations presented this fall explore the potential of facilitating the diagnostic utility of these technologies. Studies include the use of RNAscope™ for assessing B-cell clonality with IGLL5 detection, and COMET™ for spatial profiling of lymphoid malignancies using a 21-plex seqIF™ panel. These findings demonstrate how spatial biology tools can be integrated into diagnostic workflows, especially in cases with limited tissue availability.\nBio-Techne will showcase these innovations at the National Society of Histotechnology (NSH) Convention, taking place September 26–30 in Long Beach, CA. Advanced Cell Diagnostics (ACD) and Lunaphore will exhibit at booths #139 and #427, respectively.\nPresentations include:\nRNAscope™ for Routine Anatomic Pathology: Dr. Ryan Bremer will highlight the advantages of RNAscope™ over legacy RNA ISH and other methods for well-known markers and new markers of potential clinical significance, as well as the easy adoption of RNAscope into existing workflows. (Session WS29, Sep. 27, 4:45 p.m.)RNAscope™ of IGLL5 Offers New Insights in B-cell Clonality: Dr. Ishani Das has been selected for a l...