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BeyondSpring Presents New Clinical Evidence of Plinabulin Protection of Granulocyte-Monocyte Progenitor Stem Cells for the Prevention of Chemotherapy-Induced Neutropenia at the ESMO Congress 2022
Plinabulin rapidly (within 24 hours) mitigates chemotherapy-induced myelosuppression by protecting bone marrow granulocyte-monocyte progenitor (GMP) stem
About this update from Beyondspring, Inc.
[{"type":"text","content":"Plinabulin rapidly (within 24 hours) mitigates chemotherapy-induced myelosuppression by protecting bone marrow granulocyte-monocyte progenitor (GMP) stem cells\nNEW YORK, Sept. 13, 2022 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (the “Company” or “BeyondSpring”) (NASDAQ: BYSI), a clinical stage global biopharmaceutical company focused on developing innovative cancer therapies to improve clinical outcomes for patients who have a high unmet medical need, today announced data from a poster presentation at the ESMO Congress 2022 being held September 9-13, 2022, in Paris, France. The poster includes a new analysis from the Phase 2/3 PROTECTIVE-1 (NCT03102606) and PROTECTIVE-2 (NCT03294577) trials. The data provides evidence of protection of bone marrow granulocyte-monocyte progenitor (GMP) stem cells within 24 hours after chemotherapy based on an evaluation of peripheral immature and mature neutrophil counts. “We’re pleased to present mechanistic data demonstrating the effectiveness of plinabulin for the prevention of chemotherapy-induced neutropenia (CIN). The acceptance of this data by ESMO provides continued validation of our CIN program and how plinabulin can complement the current standard of care,” said Dr. Douglas Blayney, professor of medicine at Stanford University Medical School and global principal investigator for the CIN studies. “We’ve known for a while that there is a ‘gap’ in the first week of a chemotherapy cycle where G-CSF isn’t effective, and patients are left vulnerable to CIN and potentially life-threatening infections. This study shows how plinabulin has a mechanism of action (MOA) that can act within the first 24 hours by increasing the number of important cell types that can protect against potential infection. Plinabulin has continuously demonstrated how it can be a novel tool in the oncologist’s arsenal to potentially improve outcomes for these patients.” Poster Presentation Details Title: Clinical Evaluation of Plinabulin’s Granulocyte-Monocyte Progenitor (GMP) Stem Cell Effects for the Prevention of Chemotherapy-Induced Neutropenia (CIN)Presentation #: 1588PPresenter: Dr. Douglas Blayney, professor of medicine at Stanford University Medical School and global principal investigator for the CIN studies Peripheral blood counts for mature (segmented) and immature neutrophils, white blood cells (WBCs), red blood ce...