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Axim Biotechnologies Announces Phase IIa Trial Results Validating its Proprietary Cannabinoid Delivery Method for Treatment of Irritable Bowel Syndrome (IBS)
Axim Biotechnologies Announces Phase IIa Trial Results Validating its Proprietary Cannabinoid Delivery Method for Treatment of Irritable Bowel Syndrome (IBS).
About this update from Axim Biotechnologies, Inc.
[{"type":"text","content":"\n\n NEW YORK, Nov. 21, 2017 (GLOBE NEWSWIRE) -- AXIM® Biotechnologies, Inc. (AXIM® Biotech) (OTC:AXIM), a world leader in cannabinoid research and development, today announced clinical trial results from its first phase II pilot trial for the treatment of irritable bowel syndrome (IBS) with the company’s CanChew +® CBD (cannabidiol) functional, controlled release chewing gum.\n The study, which was conducted at Wageningen University in The Netherlands, was a randomized, placebo controlled, double-blind, cross-over trial aimed at investigating acceptance and overall pain reduction. Enrolled patients suffered from IBS according to the Rome III criteria, as diagnosed by their own physicians. To be included, it was also necessary that patients experienced, according to their own account, at least three pain episodes per week of a predefined intensity (measured by VAS-score).  After a one-week run-in period to record baseline parameters, patients received either CanChew+® (with 50 mg CBD) or active placebo chewing gum for periods of 3 weeks each, with a one-week “off” interval in between. Participants were asked to record effects on pain by visual analogue scale (VAS) and to fill out questionnaires on perceived quality of life (QOL) and bowel habits at regular time points. Study results indicate that CanChew+® was well tolerated by the IBS patients and no significant adverse side effects were observed by any participants of the trial. All patients who participated in the study experienced decrease in their levels of pain score. On top of the overall reduction, the trend curve suggests 50% higher pain reduction when patients were on CanChew+® compared to the active placebo, which suggests that CBD content did lend to a decrease in pain score. As overall pain scores were reduced, the study also validates AXIM’s use of its proprietary chewing gum delivery system.   “We are extremely excited to see clinical evidence of our theory and the therapeutic effects of CBD gum and mastication on IBS patients,” said Dr. George Anastassov, CEO of AXIM Biotechnologies. “We learned a great deal from this pilot study that will help us to construct the next steps in our IBS program. We plan to extend this study as an open-label trial for prolonged duration and with set d...