Business

Avacta Announces Two Key Clinical Updates to its Faridoxorubicin Program

Cardiac dosing limit removed and path forward to dose selection identifiedLONDON and PHILADELPHIA, Feb. 03, 2026 (GLOBE NEWSWIRE) -- Avacta Therapeutics (AIM: AVCT, “the Company”, “Avacta”), a clinical stage biopharmaceutical company developing pre|CISION®, a tumor-activated oncology delivery platform, has published two key clinical updates to its faridoxorubicin (AVA6000) clinical program. Agreed updates to the trial protocol include the removal of the maximum dosing limit and to allow flexibil

articleAvacta Group PlcFebruary 3, 20263/company/avacta-group-plc/news/avacta-announces-two-key-clinical-updates-to-its-faridoxorubicin-program
Avacta Announces Two Key Clinical Updates to its Faridoxorubicin Program

About this update from Avacta Group Plc

[{"type":"image","alt":"AVACTA GROUP PLC","displaySize":"","headline":null,"caption":"AVACTA GROUP PLC","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":109,"url":"https://media.zenfs.com/en/globenewswire.com/2179b51c1f91cddf1addee3cc0dee04b"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/BuJbdPFE1KPW3OqbkUSHWA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTE1MztjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/2179b51c1f91cddf1addee3cc0dee04b","width":300,"height":109}},"lazy":false},{"type":"text","content":"Cardiac dosing limit removed and path forward to dose selection identified","length":74,"tagName":"p"},{"type":"text","content":"LONDON and PHILADELPHIA, Feb. 03, 2026 (GLOBE NEWSWIRE) -- Avacta Therapeutics (AIM: AVCT, “the Company”, “Avacta”), a clinical stage biopharmaceutical company developing pre|CISION®, a tumor-activated oncology delivery platform, has published two key clinical updates to its faridoxorubicin (AVA6000) clinical program.","length":324,"tagName":"p"},{"type":"text","content":"Agreed updates to the trial protocol include the removal of the maximum dosing limit and to allow flexibility in dosing levels. These two developments underscore the growing confidence from investigators and regulators in the tolerability profile of faridoxorubicin and should support a smooth transition to future efficacy studies.","length":332,"tagName":"p"},{"type":"text","content":"The historic maximum dosing limit which is based on the patient’s exposure to released (free) doxorubicin, has been removed in the clinical trial following the collection of highly favorable safety data from the faridoxorubicin program and observation of patients receiving the highest cumulative doses for prolonged periods. Dosing in the Phase 1 clinical trial escalated to a dose of nearly 4x the conventional dose of doxorubicin and the maximum cumulative exposure of released doxorubicin was increased to 550 mg/m2 during the trial with no severe cardiac toxicity observed.","length":578,"tagName":"p"},{"type":"text","content":"One of the key advantages of the pre|CISION® platform is that its unique delivery mechanism allows patients to receive the drug for longer and at higher doses due to improved tolerability, with the potential to extend the progression free survival endpoint in trials.","length":267,"tagName":"p"},{"type":"text","co...

More updates from Avacta Group Plc

clinical programtumor microenvironmentdoxorubicinclinical updatesclinical stage