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aTyr Pharma Presents Preclinical Research Demonstrating Treatment with ATYR2810 Inhibits Tumor Growth and Therapy Resistance in Highly Aggressive Cancers at the 2023 AACR Annual Meeting
Findings demonstrate effects of ATYR2810 in models of certain forms of lung and kidney cancers SAN DIEGO, April 17, 2023 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc.
About this update from Atyr Pharma, Inc.
[{"type":"text","content":"Findings demonstrate effects of ATYR2810 in models of certain forms of lung and kidney cancers\nSAN DIEGO, April 17, 2023 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced a poster presentation at the 2023 American Association for Cancer Research (AACR) Annual Meeting, which is being held April 14 – 19, 2023, in Orlando, FL. The abstract is available on the AACR website. The poster will be available on the aTyr website once presented. The poster presents preclinical findings characterizing the inhibition of tumor growth and therapy resistance in aggressive cancers overexpressing VEGF-C treated with ATYR2810, a fully humanized monoclonal antibody that selectively and functionally blocks neuropilin-2 (NRP2) and VEGF-C signaling by directly binding at the site of the VEGF binding pocket. Treatment with ATYR2810 monotherapy and in combination with chemotherapy in a model of non-small cell lung cancer demonstrated increased tumor growth inhibition and sensitivity to chemotherapy. In a model of clear cell renal cell carcinoma, ATYR2810 in combination with the VEGFR-targeted therapy sunitinib inhibited tumor growth and led to tumor regression in some cases. These data demonstrate the potential therapeutic effects of blocking the NRP2/VEGF-C signaling axis with ATYR2810 on enhanced tumor growth inhibition and sensitivity to chemotherapy and targeted therapy. “High levels of VEGF-C are known to be associated with key features of aggressive cancers, including therapy resistance, whether this resistance is intrinsic or acquired throughout the treatment paradigm,” said Leslie A. Nangle, Ph.D., Vice President, Research, at aTyr. “While current targeted agents can block VEGF/VEGFR signaling, they do not act on VEGF/NRP2 signaling that can occur in the absence of VEGFR and is known to be a key driver of aggressive cancer. By directly blocking the interaction between VEGF and NRP2, ATYR2810 may be an effective novel therapeutic that combats resistance and reduces invasion and metastasis and may serve as a differentiated approach to targeting aggressive cancers.” Details of the poster and corresponding abstract are as follows: Title: Resistance to cancer therapy via upregulation of the ...