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aTyr Pharma Announces Publication of Two Abstracts in American Journal of Respiratory and Critical Care Medicine
Abstracts originally accepted for presentation at the 2020 American Thoracic Society (ATS) International Conference Findings confirm that aTyr’s lead clinical
About this update from Atyr Pharma, Inc.
[{"type":"text","content":"Abstracts originally accepted for presentation at the 2020 American Thoracic Society (ATS) International Conference\n Findings confirm that aTyr’s lead clinical candidate, ATYR1923, selectively binds to Neuropilin-2 (NRP2), a unique target expressed on key immune cells in inflammatory conditions SAN DIEGO, May 05, 2020 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways, today announced that two abstracts originally accepted for presentation at the 2020 ATS International Conference will be published in the ATS journal, American Journal of Respiratory and Critical Care Medicine. One abstract characterizes the molecular basis for ATYR1923’s immunomodulatory properties, including its ability to specifically and selectively bind to NRP2, a target that has been implicated in a broad range of immune-mediated diseases. The second abstract demonstrates that NRP2 is expressed on key immune cells in inflammatory conditions, including sarcoidosis granulomas, reinforcing its status as a key target in the treatment of immune-mediated diseases. “We are very pleased to have these abstracts, which were originally accepted for presentation at the ATS International Conference, published in the highly-regarded American Journal of Respiratory and Critical Care Medicine,” stated Dr. Sanjay Shukla, M.D., M.S., President and Chief Executive Officer of aTyr. “The findings summarized in these abstracts confirm the significant role of NRP2 in serious inflammatory diseases, and further elucidate the mechanism of action of ATYR1923 in its ability to selectively bind to this unique target. We look forward to final results from our ongoing Phase 1b/2a clinical trial of ATYR1923 in patients with pulmonary sarcoidosis while in parallel leveraging our numerous research collaborations with biopharmaceutical leaders and academia to further expand our pre-clinical pipeline.” Details of the abstracts are as follows: P1173 - ATYR1923 Specifically Binds to Neuropilin-2, a Novel Therapeutic Target for the Treatment of Immune-Mediated DiseasesNeuropilin-2 (NRP2) is a pleiotropic cell surface receptor known to be expressed on a number of different immune cell types that plays a key role in regulating inflammatory responses. aTyr Pharma’s lea...