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aTyr Pharma Announces Publication of Positive Data from Phase 1b/2a Clinical Study of Efzofitimod for the Treatment of Pulmonary Sarcoidosis in the Journal CHEST
First therapy in sarcoidosis to reduce steroid burden while demonstrating improvements in key physiologic and quality of life measures. Global pivotal Phase 3
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[{"type":"text","content":"First therapy in sarcoidosis to reduce steroid burden while demonstrating improvements in key physiologic and quality of life measures. Global pivotal Phase 3 EFZO-FIT™ study currently enrolling. SAN DIEGO, Nov. 09, 2022 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced the publication in the journal CHEST of positive results from a Phase 1b/2a randomized, double-blind, placebo-controlled clinical trial of its lead therapeutic candidate, efzofitimod, in patients with pulmonary sarcoidosis, a major form of interstitial lung disease. The publication, entitled, “Efzofitimod for the treatment of pulmonary sarcoidosis,” is available on the journal’s website and at: https://doi.org/10.1016/j.chest.2022.10.037. “The dose-dependent improvements of several clinically relevant endpoints seen with efzofitimod compared to placebo, along with the desirable safety and tolerability profile, are very important findings,” said Daniel A. Culver, D.O., Chair of the Department of Pulmonary Medicine at The Cleveland Clinic and lead author of the publication. “The ongoing EFZO-FIT™ study presents the opportunity to evaluate the steroid sparing effects of efzofitimod in a broader clinical trial. We are hopeful that this study will lead to a safe and effective treatment that reduces steroid burden and has a major impact on quality of life for patients with pulmonary sarcoidosis, which is greatly needed.” The study demonstrated that efzofitimod was safe and well-tolerated at all doses and exhibited a consistent dose response on key efficacy endpoints and improvements compared to placebo, including measures of steroid reduction, lung function, sarcoidosis symptom measures and inflammatory biomarkers. “The publication of this manuscript marks the first peer-reviewed publication of clinical data for efzofitimod in a major medical journal. These data indicate that efzofitimod is providing substantial benefit to patients — improving lung function and symptoms of cough, shortness of breath and fatigue — all while reducing their toxic steroid burden,” said Sanjay S. Shukla, M.D., M.S., President and Chief Executive Officer of aTyr. “EFZO-FIT™ is expected to be the largest interventional study for pati...