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aTyr Pharma Announces Grant of U.S. Patent for Use of Histidyl-tRNA Synthetase Fc Fusion Proteins for Reducing Inflammatory Response in the Lung
SAN DIEGO, July 29, 2021 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of
About this update from Atyr Pharma, Inc.
[{"type":"text","content":"SAN DIEGO, July 29, 2021 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways, today announced that the U.S. Patent and Trademark Office (USPTO) has granted a patent covering methods for the use of histidyl-tRNA synthetase Fc fusion proteins for reducing inflammatory response in the lung. The patent, U.S. Patent No. 11,072,787 entitled, “Histidyl-tRNA synthetase-FC conjugates,” covers the use of the company’s lead therapeutic candidate, ATYR1923, for reducing inflammatory response in the lung. ATYR1923 is a Fc fusion protein based on the N terminal fragment of histidyl-tRNA synthetase that is currently in clinical development for the treatment of pulmonary sarcoidosis and is being evaluated in other inflammatory lung diseases. “We are pleased with the USPTO grant of this patent covering the use of ATYR1923 to treat inflammatory response in the lung, which builds upon our growing intellectual property estate on this lead molecule series,” said Sanjay S. Shukla, M.D., M.S., President and Chief Executive Officer of aTyr. aTyr’s global patent estate includes over 220 issued or allowed patents owned or exclusively licensed by aTyr and its Hong Kong subsidiary, Pangu BioPharma Limited, developed over a decade of research and development activities. This patent estate highlights aTyr’s unique leadership position in this emerging area of biology. These patents encompassed important new therapeutic modalities which underpin the broad pipeline of novel therapeutics in active development at the company. About ATYR1923 aTyr is developing ATYR1923 as a potential therapeutic for patients with inflammatory lung diseases. ATYR1923, a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody, is a selective modulator of Neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states. aTyr recently completed enrollment in a proof-of-concept Phase 1b/2a trial evaluating ATYR1923 in patients with pulmonary sarcoidosis. This Phase 1b/2a study is a multi-ascending dose, placebo-controlled, first-in-patient study of ATYR1923 that has been designed to evaluate the safety, tolerability, steroid sparing effect, immunogenic...