Business
Atea Pharmaceuticals Presents Promising Bemnifosbuvir and Ruzasvir Combination Data for the Treatment of Hepatitis C Virus at AASLD The Liver Meeting 2023
First Clinical Data for Coadministration of Bemnifosbuvir and Ruzasvir Show Combination Was Well Tolerated in a Phase 1 Study Plasma Pharmacokinetic (PK)
About this update from Atea Pharmaceuticals, Inc.
[{"type":"text","content":"First Clinical Data for Coadministration of Bemnifosbuvir and Ruzasvir Show Combination Was Well Tolerated in a Phase 1 Study Plasma Pharmacokinetic (PK) Profiles of Bemnifosbuvir and Ruzasvir Were Not Affected by Food or Concomitant Dosing, Indicating Low Risk of Drug-Drug Interactions Bemnifosbuvir and Ruzasvir are Potent Direct Acting Antivirals In Vitro with Favorable Antiviral Profiles Against HCV NS5A and NS5B Resistant Associated Variants (RAVs) BOSTON, Nov. 13, 2023 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) (Atea), a clinical-stage biopharmaceutical company engaged in the discovery and development of oral antiviral therapeutics for serious viral diseases, today announced the presentation of two posters supporting the combination of bemnifosbuvir, an oral nucleotide polymerase inhibitor, and ruzasvir, an oral NS5A inhibitor, as a potential treatment for Hepatitis C Virus (HCV) at the American Association for the Study of Liver Diseases’ (AASLD) The Liver Meeting 2023, being held from November 10-14, 2023 in Boston, MA. “Results from these two presented studies further support the potential use of these two drug candidates in combination as a novel treatment for HCV. Phase 1 data demonstrate that coadministration of bemnifosbuvir and ruzasvir was well tolerated and not affected by food or concomitant dosing, indicating a low risk of drug-drug interactions,” said Jean-Pierre Sommadossi, PhD, Chief Executive Officer and Founder of Atea Pharmaceuticals. “Moreover, in vitro data demonstrate that the combination of bemnifosbuvir and ruzasvir retained potent pan-genotypic antiviral activity against major HCV NS5A and NS5B resistance-associated variants and hard-to-treat sub-genotypes, which have been identified in certain HCV patients who have failed treatment with currently available therapies.” “We are very pleased with the substantial progress achieved in our Phase 2 combination study of bemnifosbuvir and ruzasvir for the treatment of HCV this year, and we expect to announce results from the 60-person lead-in cohort in early 2024,” continued Dr. Sommadossi. “We look forward to progressing the clinical development of this potent direct-acting antiviral combination for the potential benefit for millions of patients who, despite available treatments for HCV, remain underserved.” Poster Number: 1879-ADate and ...