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Atea Pharmaceuticals Announces First Patient Dosed in SUNRISE-3 Phase 3 Registrational Trial of Bemnifosbuvir, an Investigational Oral Antiviral for the Treatment of COVID-19
Global Study to Evaluate Bemnifosbuvir as Monotherapy and in Combination in Non-Hospitalized Patients at High Risk of Disease Progression, Regardless of
About this update from Atea Pharmaceuticals, Inc.
[{"type":"text","content":"Global Study to Evaluate Bemnifosbuvir as Monotherapy and in Combination in Non-Hospitalized Patients at High Risk of Disease Progression, Regardless of Vaccination Status Phase 3 Evaluation of Bemnifosbuvir Supported by Clinical Data from Late-Stage MORNINGSKY Trial and Prior Studies Bemnifosbuvir’s Unique Mechanism with Dual Targets Creates a Higher Barrier to Resistance and Retains Antiviral Activity Against COVID-19 Variants BOSTON, Nov. 29, 2022 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) (“Atea”), a clinical-stage biopharmaceutical company, today announced the enrollment of the first patient in the SUNRISE-3 Phase 3 trial, a global multicenter trial evaluating bemnifosbuvir (AT-527) for the treatment of COVID-19 in non-hospitalized patients at high risk for disease progression to hospitalization and death. The patient was enrolled and dosed at a U.S. clinical trial site. The study is designed to enroll at least 1,500 patients with mild or moderate COVID-19, and the primary endpoint is all-cause hospitalization or death through Day 29 in at least 1,300 patients in the monotherapy arm. Bemnifosbuvir is an investigational orally administered, direct-acting antiviral derived from Atea’s purine nucleotide prodrug platform. “Our COVID-19 strategy for bemnifosbuvir is to focus on the highest unmet medical need. Our goal is to deliver a safe, effective and convenient treatment option for people that remain vulnerable to hospitalization or death due to the limitations of current antiviral treatments and the ability of the virus to evade vaccines and monoclonal antibodies,” said Jean-Pierre Sommadossi, PhD, Chief Executive Officer and Founder of Atea Pharmaceuticals. “New variants not susceptible to currently available preventive tools are driving COVID-19 infection waves, which should enable timely patient enrollment in SUNRISE-3.” “COVID-19 remains a significant cause of morbidity and mortality, particularly in the elderly and immunocompromised. New oral antivirals, with improved profiles, are urgently needed to help those for whom currently available treatments are either unsuitable or ineffective,” said Robert Murphy, MD, Executive Director of the Havey Institute for Global Health and the John Philip Phair Professor of Infectious Diseases at Northwestern University Feinberg School of Medicine. Bemnifosbuvir, a ...