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Atara Biotherapeutics Announces Presentation of Late-Breaking Preclinical Data on ATA2271, a Next-Generation Autologous CAR T Immunotherapy Targeting Mesothelin, at the American Association for Cancer Research (AACR) Virtual Annual Meeting II 2020
First published data with novel 1XX CAR signaling and programmed death-1 (PD-1) dominant negative receptor (DNR) checkpoint inhibition technologies Evidence
About this update from Atara Biotherapeutics, Inc.
[{"type":"text","content":"\nFirst published data with novel 1XX CAR signaling and programmed death-1 (PD-1) dominant negative receptor (DNR) checkpoint inhibition technologies\n\n\nEvidence of preclinical safety, improved functional characteristics and enhanced antitumor efficacy of ATA2271\n\n\nData support IND filing and future ATA2271 Phase I clinical trial enrollment in mesothelioma\n\n SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--\nAtara Biotherapeutics, Inc. (Nasdaq: ATRA), a pioneer in T-cell immunotherapy leveraging its novel allogeneic EBV T-cell platform to develop treatments for patients with severe diseases including solid tumors, hematologic cancers and autoimmune disease, today announced that an abstract describing the preclinical safety, improved functional characteristics and antitumor efficacy of ATA2271, a next-generation autologous chimeric antigen receptor (CAR) T cell therapy targeting mesothelin, was selected for a late-breaking poster presentation at the second American Association for Cancer Research (AACR) Virtual Annual Meeting 2020 to be held on June 22-24, 2020.\n\n\nAlthough CAR T cell therapies have been approved for certain hematologic malignancies, new approaches are needed in solid tumor settings. Mesothelin is a tumor-specific antigen that is commonly expressed at high levels on the cell surface in many aggressive solid tumors including mesothelioma. Atara has selected mesothelin as the target for both the ATA2271 autologous and the ATA 3271 allogeneic programs along with novel CAR T-cell technologies to further enhance activity.\n\n\nData being presented for the first time at AACR detail results from IND-enabling preclinical studies with ATA2271 technologies, designed to help overcome current CAR T challenges with targeting solid tumors, including the novel 1XX CAR signaling domain and a dominant-negative programmed death-1 receptor (PD1DNR). These studies, led by Prasad Adusumilli, MD and collaborators at Memorial Sloan Kettering Cancer Center (MSK) provide both in vitro and in vivo evidence of the preclinical safety, improved functional characteristics and enhanced anti-tumor efficacy of ATA2271.\n\n\n“These data support the combined addition of novel design elements in this next-gen CAR T therapy, including both 1XX co-stimulatory signaling and PD1DNR, that were associated with less cell exhaustion, improvements in ...