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Atara Biotherapeutics Announces FDA Clearance of IND for ATA2271, a Next-Generation Autologous Mesothelin-Targeted CAR T with Novel PD1DNR and 1XX Technologies Combined to Treat Solid Tumors
First CAR T therapy leveraging combination of cell intrinsic PD1DNR checkpoint inhibition and 1XX CAR signaling technologies to enter the clinic Atara’s
About this update from Atara Biotherapeutics, Inc.
[{"type":"text","content":"\nFirst CAR T therapy leveraging combination of cell intrinsic PD1DNR checkpoint inhibition and 1XX CAR signaling technologies to enter the clinic \n\n\nAtara’s next-generation CAR T program targets Mesothelin, a highly-expressed antigen on the cell surface of many aggressive solid tumors\n\n\nEvidence of preclinical safety, improved functional characteristics and enhanced antitumor efficacy of ATA2271 from IND-enabling studies were recently presented at the 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting II\n\n SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--\nAtara Biotherapeutics, Inc. (Nasdaq: ATRA), a pioneer in T-cell immunotherapy leveraging its novel allogeneic EBV T-cell platform to develop treatments for patients with severe diseases including solid tumors, hematologic cancers and autoimmune disease, today announced that the U.S. Food and Drug Administration (FDA) has accepted the Investigational New Drug (IND) application providing clearance to initiate an open-label, single-arm Phase 1 clinical study of ATA2271, the Company’s next-generation autologous CAR T therapy targeting mesothelin under development in collaboration with Memorial Sloan Kettering Cancer Center (MSK), for the treatment of advanced mesothelioma.\n\n\n“We are pleased the FDA has cleared the IND for ATA2271 for the treatment of advanced mesothelioma,” said Jakob Dupont, Global Head of Research and Development, Atara Biotherapeutics. “This milestone marks an important moment in the advancement of cell and gene immunotherapy for patients, for the field and for Atara. As the first-ever CAR T therapy leveraging the combination of PD1DNR checkpoint inhibition and 1XX CAR signaling technologies to enter the clinic, we are advancing such a unique CAR T program with the goal of developing transformative therapies for patients with solid tumors.”\n\n\nThis novel next-generation autologous, mesothelin-targeted CAR T therapy was developed in collaboration with researchers at MSK, Dr. Prasad Adusumilli, who led two trials with first-generation mesothelin CAR T therapy and engineered T-cell intrinsic checkpoint blockade by PD1DNR to overcome the immune suppression of PDL1, and Dr. Michel Sadelain, a leader in the CAR T-cell field who developed the 1XX co-stimulatory domain technology to extend T-cell effector function while limiting cell...