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Ascletis Announces First Participants with Obesity or Overweight Dosed in Its U.S. 12-week Phase IIa Study Evaluating Once-Monthly Subcutaneous Depot Formulation of Small Molecule GLP-1R Agonist ASC30
Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") announces today that the first participants with obesity or overweight with at least one weight-related comorbidity have been dosed in its U.S. 12-week Phase IIa study with once-monthly subcutaneous (SQ) depot formulation of small molecule GLP-1 receptor (GLP-1R) agonist ASC30 for the treatment of obesity (NCT06679959).
About this update from Ascletis Pharma, Inc.
[{"type":"text","content":"- First participants with obesity or overweight with at least one weight-related comorbidity have been dosed in a U.S. 12-week Phase IIa study with once-monthly subcutaneous (SQ) depot formulation of small molecule GLP-1 receptor agonist ASC30. ","length":298,"tagName":"p"},{"type":"text","content":"- Ultra-long-acting SQ depot formulation of small molecule ASC30 demonstrated a 36-day half-life in participants with obesity in the Phase Ib study, supporting once monthly administration. ","length":227,"tagName":"p"},{"type":"text","content":"- Phase Ib study also demonstrated that compared to the trough concentration of ASC30 at Day 29, the ultra-long-acting SQ depot formulation showed a peak-to-trough ratio less than 2:1.","length":238,"tagName":"p"},{"type":"text","content":"- Topline data from the 12-week Phase IIa study of ASC30 once-monthly SQ depot formulation are expected in the first quarter of 2026.","length":197,"tagName":"p"},{"type":"text","content":"HONG KONG, July 27, 2025 /PRNewswire/ -- Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") announces today that the first participants with obesity or overweight with at least one weight-related comorbidity have been dosed in its U.S. 12-week Phase IIa study with once-monthly subcutaneous (SQ) depot formulation of small molecule GLP-1 receptor (GLP-1R) agonist ASC30 for the treatment of obesity (NCT06679959).","length":443,"tagName":"p"},{"type":"text","content":"In the completed U.S. Phase Ib single ascending dose (SAD) study, the ultra-long-acting SQ depot formulation of small molecule ASC30 demonstrated a 36-day half-life in participants with obesity, supporting once monthly administration (Press Release). Furthermore, the U.S. Phase Ib SAD study demonstrated that compared to the trough concentration of ASC30 at Day 29, the ultra-long-acting SQ depot formulation showed a peak-to-trough ratio less than 2:1. The proprietary SQ depot slow-release formulation of ASC30 was developed by Ascletis' Ultra-Long-Acting Platform (ULAP). Utilizing this innovative platform, Ascletis has successfully designed and devel...