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Artelo Biosciences Doses First Patient in CAReS Study with ART27.13 for the Treatment of Cancer-Related Anorexia and Weight Loss
Initial safety data expected from CAReS Study before end of 2021 Targeting multi-billion market with no approved therapies for cancer-related anorexia LA
About this update from Artelo Biosciences, Inc.
[{"type":"text","content":"Initial safety data expected from CAReS Study before end of 2021 Targeting multi-billion market with no approved therapies for cancer-related anorexia LA JOLLA, Calif., April 12, 2021 (GLOBE NEWSWIRE) -- Artelo Biosciences, Inc. (NASDAQ: ARTL), a clinical stage biopharmaceutical company focused on the development of therapeutics that target lipid-signaling signaling pathways, including the endocannabinoid system, today announced that the first patient has been dosed in the Company’s Phase 1/2 Cancer Appetite Recovery Study (CAReS) of ART27.13 in Edinburgh, Scotland, UK. ART27.13 is a peripherally selective G-Protein Coupled Receptor (GPCR) full agonist that is being developed as a much-needed therapy for cancer patients suffering from anorexia and weight loss, which affects over 60% of later-stage cancer patients, often impacts quality of life, and can hasten death. “Commencing enrollment and dosing the first patient in our CAReS study marks another important milestone in advancing ART27.13, which we are developing for patients suffering from the devastating effects of cancer associated anorexia—a multi-billion-dollar addressable market with no pharmacologic standard of care,” stated Andrew Yates, Ph.D., Senior Vice President and Chief Scientific Officer of Artelo. “Notably, we anticipate that we will be able to collect initial safety data from Phase 1 of CAReS before the end of this year, which will determine the most effective and safest dose of ART27.13 to utilize in Phase 2 of the study. ART27.13 has previously demonstrated weight gain in subjects with lower back pain and we look forward to conducting the study in anorexic cancer patients who have suffered significant weight loss.” \"This is an exciting time for a clinical study with Artelo’s lead development drug. So many patients have suffered with substandard options to address the profound weight loss from cancer. With ART27.13 there are grounds for optimism that loss of appetite associated with cancer can be successfully treated,\" added the lead investigator Barry J.A. Laird, M.D., from the Institute of Genetics and Cancer at the University of Edinburgh, Scotland and enrolling physician of the first participating patient. About ART27.13ART27.13 is a highly potent, peripherally restricted synthetic, dual GPCR agonist believed to target the cannabinoid receptors CB1/CB2,...