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First Patient Dosed in ACCEL: Phase 3 Chronic Idiopathic Constipation Study of IBSRELA
WALTHAM, Mass., Jan. 28, 2026 (GLOBE NEWSWIRE) -- Ardelyx, Inc. (Nasdaq: ARDX), a biopharmaceutical company founded with a mission to discover, develop and commercialize innovative, first-in-class medicines that meet significant unmet medical needs, today announced that the first patient has been dosed in ACCEL (ten-03-301), a Phase 3 clinical trial designed to assess the safety and efficacy of IBSRELA® (tenapanor) for the treatment of chronic idiopathic constipation (CIC) in adults. ACCEL is a
About this update from Ardelyx, Inc.
[{"type":"image","alt":"Ardelyx, Inc.","displaySize":"","headline":null,"caption":"Ardelyx, Inc.","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":69,"url":"https://media.zenfs.com/en/globenewswire.com/0b16c7d3f50416d895ec92e34e19858e"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/MgPvxPnNoevfPj4GVpeYhQ--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTk3O2NmPXdlYnA-/https://media.zenfs.com/en/globenewswire.com/0b16c7d3f50416d895ec92e34e19858e","width":300,"height":69}},"lazy":false},{"type":"text","content":"WALTHAM, Mass., Jan. 28, 2026 (GLOBE NEWSWIRE) -- Ardelyx, Inc. (Nasdaq: ARDX), a biopharmaceutical company founded with a mission to discover, develop and commercialize innovative, first-in-class medicines that meet significant unmet medical needs, today announced that the first patient has been dosed in ACCEL (ten-03-301), a Phase 3 clinical trial designed to assess the safety and efficacy of IBSRELA® (tenapanor) for the treatment of chronic idiopathic constipation (CIC) in adults.","length":488,"tagName":"p"},{"type":"text","content":"ACCEL is a multicenter, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of tenapanor for the treatment of CIC in adults when administered twice daily for 26 consecutive weeks. The Phase 3 clinical trial is designed to enroll approximately 700 patients with CIC. The primary endpoint will evaluate patient-reported outcomes in constipation. Enrollment in ACCEL is expected throughout 2026, with topline data read out in the second half of 2027.","length":480,"tagName":"p"},{"type":"text","content":"“Today marks an important milestone for our team and the patients we are committed to serving,” said Laura Williams, M.D., M.P.H, chief patient officer and interim chief medical officer of Ardelyx. “We are pleased to announce that the first patient has been dosed in the ACCEL Phase 3 clinical trial, an integral step to bringing IBSRELA and its differentiated mechanism of action to patients with chronic idiopathic constipation. This achievement reflects the dedication of our investigators, clinical staff, internal team, and most importantly, the patients and families who entrust us with their care. We remain focused on conducting this study with the highest standards of safety, integrity and scientific rigor, and we look forward to the insights it will provide for ...