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Ardelyx Presents Positive Data at DDW 2023 on IBSRELA® (tenapanor), a First-In-Class Treatment for IBS-C in Adults
IBSRELA provides meaningful reduction of multiple abdominal symptoms Patient-reported outcomes are strongly correlated with IBS-C abdominal symptom score
About this update from Ardelyx, Inc.
[{"type":"text","content":"IBSRELA provides meaningful reduction of multiple abdominal symptoms Patient-reported outcomes are strongly correlated with IBS-C abdominal symptom score WALTHAM, Mass., May 09, 2023 (GLOBE NEWSWIRE) -- Ardelyx, Inc. (Nasdaq: ARDX), a biopharmaceutical company founded with a mission to discover, develop and commercialize innovative, first-in-class medicines that meet significant unmet medical needs, today announced that a new analysis from IBSRELA Phase 3 trial, T3MPO-2, was presented in a poster presentation at the 2023 Digestive Disease Week Conference (DDW 2023) that is now underway in Chicago, Illinois. IBSRELA, discovered and developed by Ardelyx, is a first-in-class treatment with a novel mechanism and triple action that is approved by the U.S. Food and Drug Administration to treat irritable bowel syndrome with constipation (IBS-C) in adults. “Abdominal symptoms of IBS-C, including pain, bloating and discomfort, can have an extremely negative impact on patients’ quality of life,” said Brian E. Lacy, M.D., Ph.D., Professor of Medicine, Mayo Clinic. “The data presented in this poster demonstrate that patients treated with IBSRELA experienced significant improvement in abdominal symptoms and that this improvement correlates with patient reports of adequate relief. This data analysis provides further evidence of the important role IBSRELA, with its novel mechanism of action, can play in the treatment of IBS-C.” Ardelyx Poster #Tu1618, entitled “Analysis of Patient-Reported Treatment Satisfaction and Abdominal Score in Patients with Irritable Bowel Syndrome with Constipation (IBS-C) with Tenapanor,” reported results from a post hoc analysis of the T3MPO-2 study of IBSRELA in adult patients with IBS-C to examine the relationship between patient-reported satisfaction (as measured by adequate relief and degree of relief) and improvement in abdominal symptoms. The Phase 3 T3MPO-2 study randomized patients to tenapanor 50 mg twice a day or matched placebo for 26 weeks of treatment. The analysis demonstrated that IBSRELA meaningfully reduced multiple abdominal symptoms in patients with IBS-C, including bloating, discomfort and pain, compared to placebo. The analysis also indicates that patient-reported treatment satisfaction was strongly correlated with the IBS-C abdominal score (AS3, combining mean weekly abdominal pain, bloating an...