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Arcutis Announces Enrollment of First Patient in Topical Roflumilast Cream Phase 3 Open Label Extension Study in Plaque Psoriasis
Topical Roflumilast Cream (ARQ-151) Potential “Best in Class” Topical PDE4 inhibitorRoflumilast Cream Potentially Only Topical PDE4 inhibitor for
About this update from Arcutis Biotherapeutics, Inc.
[{"type":"text","content":"Topical Roflumilast Cream (ARQ-151) Potential “Best in Class” Topical PDE4 inhibitorRoflumilast Cream Potentially Only Topical PDE4 inhibitor for PsoriasisOpen Label Extension Study to Support Potential Recommendations for Long-term Use of Roflumilast Cream WESTLAKE VILLAGE, Calif., Feb. 13, 2020 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT), a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology, today announced it has enrolled the first patient in an open label extension study, DERMIS-OLE, evaluating topical roflumilast cream (ARQ-151) as a potential treatment for plaque psoriasis. Roflumilast cream, Arcutis’ lead product candidate, is a highly potent and selective phosphodiesterase type 4 inhibitor (“PDE4 inhibitor”) once-daily topical cream.\n\n \n \n \n \n \n \n \n \n \n \n \n We believe roflumilast cream has the potential to be a once daily treatment that benefits patients with plaque psoriasis who currently lack suitable treatment options.\n \n \n \n \n \n \n \n \n\n Howard Welgus, M.D., Arcutis’ Chief Medical Officer, commented: “Psoriasis can be difficult to treat with topical agents, which are often limited by inadequate efficacy, poor safety and tolerability, or both. In clinical trials, topical roflumilast cream has demonstrated an efficacy and tolerability profile that may offer meaningful improvements over existing topical treatments to patients with plaque psoriasis. We are conducting a Phase 3 program with roflumilast cream, including two registrational Phase 3 studies in plaque psoriasis called DERMIS-1 and DERMIS-2, and intend to use the results from the DERMIS open label extension study to support potential recommendations for long-term use of roflumilast cream in patients with this chronic disease. We believe roflumilast cream has the potential to be a once daily treatment that benefits patients with plaque psoriasis who currently lack suitable treatment options.” Topical roflumilast cream (ARQ-151) contains the highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor roflumilast, which has been approved globally for the systemic treatment of chronic obstructive pulmonary disease (COPD) since 2011 and which is many-fold more potent than any other...