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Arbutus to Present AB-729 and AB-161 Data at the Global Hepatitis Summit 2023
Two oral presentations scheduled for Thursday, April 27, 2023 WARMINSTER, Pa., April 18, 2023 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq:
About this update from Arbutus Biopharma Corporation
[{"type":"text","content":"Two oral presentations scheduled for Thursday, April 27, 2023 WARMINSTER, Pa., April 18, 2023 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced that two abstracts have been accepted as late-breaker oral presentations at the Global Hepatitis Summit 2023 taking place April 25-28, 2023, in Paris. The accepted abstracts for oral presentations are as follows: Abstract Number: LB/O99Session Title: Clinical 4: New HBV drug clinical developmentsSession Date/Time: Thursday, April 27, 2023, 9:20 – 9:35 amTitle: 48 weeks of AB-729+nucleos(t)ide analogue (NA) therapy results in profound, sustained HBsAg declines in both HBeAg+ and HBeAg- subjects which are maintained in HBeAg- subjects who have discontinued all therapy Presenter: Prof. Man-Fung YuenKey Findings: Data from HBeAg+ subjects (Cohort K) from the AB-729-001 clinical trial showed that AB-729 treatment leads to marked HBsAg and HBeAg declines in HBeAg+ subjects, with two subjects each achieving HBsAg and HBeAg below the limit of quantitation. Additional follow-up data reported for the seven remaining HBeAg- subjects from other cohorts who elected to stop NA therapy after NA+AB-729 treatment, showed that they continue to maintain low HBV DNA levels off all therapy, and mean HBsAg levels remain 1.55 log10 below baseline levels up to one and half years after the last dose of AB-729. Abstract Number: LB/O95Session Title: Late Breaker Abstracts SessionSession Date/Time: Thursday, April 27, 2023, 4:45 – 5:00 pmTitle: Preclinical antiviral profiling of AB-161, an oral HBV inhibitor that destabilizes HBV RNA and suppresses HBsAgPresenter: Angela M. LamKey Findings: Preclinical antiviral and mechanism of action studies were conducted for AB-161, a potent small-molecule HBV RNA destabilizer being developed as an orally administered antiviral agent for the treatment of chronic hepatitis B virus (cHBV) infection. The results showed that AB-161 provides robust anti-HBV activity including suppression of HBV RNA and HBsAg production in vitro and in vivo. The differentiated anti-HBV effects of AB-161 compared to other classes of HBV inhibitors, including nucleos(t)ide analogs (NA) and capsid assembly modulators (CA...