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Apollomics Announces Vebreltinib Data at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
Data from Phase 2 and 2/3 trials demonstrate continued efficacy and safety of vebreltinib for treating different tumor types carrying MET-driver alterations
About this update from Apollomics Inc.
[{"type":"text","content":"Data from Phase 2 and 2/3 trials demonstrate continued efficacy and safety of vebreltinib for treating different tumor types carrying MET-driver alterations\nFOSTER CITY, Calif., June 04, 2024 (GLOBE NEWSWIRE) -- Apollomics Inc. (Nasdaq: APLM) (“Apollomics” or the “Company”), a late-stage clinical biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, announced a poster presentation and an oral presentation by partner company, Avistone Biotechnology, at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, being held May 31-June 4, 2024, in Chicago, Ill. and virtually. Copies of the poster and oral presentation are available on the Apollomics website at ir.apollomicsinc.com/news-events/presentations. “Vebreltinib continues to display impressive selectivity and efficacy against multiple tumor types, demonstrating its high potential to treat a range of MET-altered tumors,” said Guo-Liang Yu, PhD, Chairman and Chief Executive Officer of Apollomics. “We believe this data highlights vebreltinib as a potential agent to treat both non-small cell lung cancer (NSCLC) patients and previously treated glioblastoma (GBM) patients and we remain excited about its continued clinical development.” The poster presentation, titled “Efficacy and safety of vebreltinib in patients with advanced NSCLC harboring MET exon 14-skipping: Results of 2.5-year follow-up in KUNPENG”, demonstrated vebreltinib consistently showed promising efficacy and favorable safety in NSCLC patients with MET exon 14-skipping mutations. Patients in cohort 1 of the Phase 2, open-label, multi-cohort study, received 200 mg of vebreltinib twice daily. The primary endpoint was overall response rate (ORR) and was assessed by blinded independent review committee (BIRC). Per BIRC assessment, the ORR was at 75%, and subgroup analyses showed the ORR was 100.0%, 66.7%, 85.7% and 100.0% among patients with any baseline brain metastases (N=5), patients with any baseline liver metastases (N=6), patients aged 75 years and older (N=21) and patients with co-occurring of MET amplification (N=12), respectively. Other efficacy parameters included disease control rate (DCR) of 96.2%, the median duration of response (DoR) of 16.5 months, the median time to response (TTR) of 1.0 month and the median progr...