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ANI Pharmaceuticals Announces Presentation of Preclinical Data on the Use of Purified Cortrophin® Gel in an Experimental Autoimmune Uveitis (EAU) Mouse Model
Demonstrated Dose Dependent Effect in EAU Presented in a podium presentation at The Association for Research in Vision and Ophthalmology (ARVO) 2025 annual
About this update from Ani Pharmaceuticals, Inc.
[{"type":"text","content":"Demonstrated Dose Dependent Effect in EAU Presented in a podium presentation at The Association for Research in Vision and Ophthalmology (ARVO) 2025 annual meeting PRINCETON, N.J., May 05, 2025 (GLOBE NEWSWIRE) -- ANI Pharmaceuticals, Inc. (ANI or the Company) (Nasdaq: ANIP) today announced preclinical data on the use of Purified Cortrophin® Gel (repository corticotropin injection USP) (Cortrophin Gel) in an EAU mouse model. “In a preclinical model of autoimmune uveitis, Cortrophin Gel reduced levels of inflammatory molecules without stimulating an adverse immune response,” said Mary Pao, MD, PhD, Chief Medical Officer of Rare Disease at ANI. “The results further support our understanding of Cortrophin Gel’s mechanism of action.” An experimental autoimmune uveitis (EAU) mouse model was used to determine the impact of four doses (4, 40, 160 or 400 U/kg) of repository corticotrophin injection (RCI, an equivalent to Cortrophin Gel in this model). The results showed a significant dose-dependent effect on the suppression of EAU at all doses, with the greatest suppression of EAU at the 400 U/kg dose. RCI also significantly suppressed the production of cytokines implicated in inflammation and immune system activation. Additionally, 400 U/kg Purified Cortrophin Gel treatment suppressed retinal damage caused by EAU, similar to α-MSH treatment, compared to placebo. “The data presentation at ARVO is part of ANI’s broader commitment to clinical research for our products and, specific to Cortrophin Gel, we are committed to building on the scientific evidence and clinical data supporting its mechanism of action and clinical use,” said Nikhil Lalwani, President and Chief Executive Officer at ANI. The data were presented yesterday in a podium presentation by Andrew W. Taylor, PhD at The Association for Research in Vision and Ophthalmology (ARVO) 2025 annual meeting being held May 4-8, 2025 in Salt Lake City, UT. Dr. Taylor is the Sarkis J. Kechejian Professor; Associate Dean of Research; and Professor & Vice-Chair of Research, Department of Ophthalmology at Boston University Chobanian & Avedisian School of Medicine. Presentation Title: The Therapeutic Effects of Purified Cortrophin® Gel on Experimental Autoimmune UveitisSession Title: Innovative Strategies For Modulating Ocular InflammationPresentation #: 896Presentation Time: Sunday, May 4, 20...