Press release
Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference
ANAVEX®2-73 corrects directly to humans’ translatable EEG biomarkers in a model of Fragile X Syndrome (FXS) Therapeutic potential to address behavioral and
About this update from Anavex Life Sciences Corp.
[{"type":"text","content":"ANAVEX®2-73 corrects directly to humans’ translatable EEG biomarkers in a model of Fragile X Syndrome (FXS) Therapeutic potential to address behavioral and cognitive deficits in individuals with neurodevelopmental disorders Plans advancing to initiate a clinical trial in individuals with FXS NEW YORK, July 30, 2024 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of Alzheimer's disease, Parkinson's disease, schizophrenia, neurodevelopmental, neurodegenerative, and rare diseases, including Rett syndrome and Fragile X syndrome (FXS), a major cause of autism, today reported positive preclinical results in directly to humans’ translatable biomarkers for individuals with FXS for ANAVEX®2-73 (blarcamesine), in a disease model of Fragile X syndrome (FXS). Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the most frequent single gene cause of autism spectrum disorder with an estimated population of approximately 62,500 in the US and 1,088,500 worldwide.1 It is characterized by a range of cognitive, behavioral, and sensory challenges, including learning difficulties, anxiety, hyperactivity, and sensitivity to sensory stimuli. At present, there is no approved treatment for Fragile X syndrome. The findings presented at the 19th NFXF International Fragile X Conference reports positive results in directly to humans’ translatable electroencephalogram (EEG) biomarkers present in both individuals with FXS and animal models of FXS. The study presented investigated the effects of ANAVEX®2-73 on brain activity in a mouse model of FXS using electroencephalography (EEG), a non-invasive technique that measures electrical signals in the brain. EEG recordings from mice treated with ANAVEX®2-73 showed significant dose-dependent improvements in several key biomarkers of brain function compared to untreated mice. Key results were found in the auditory steady state response (ASSR) EEG test, which are of particular importance to the treatment of CNS disorders. In FXS and other CNS disorders, the brain is unable to synchronize sensory stimuli like sounds appropriately, driving sensory overload and hypersensitivity in affected individuals. In the current study, ANAVEX®2-73 robust...