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Anavex Life Sciences Announces Publication of Foundational Data for ANAVEX®2-73 (blarcamesine) in Multiple Sclerosis (MS)
Published in Journal of Neuroimmunology, Results Highlight ANAVEX®2-73 (blarcamesine) Shown to Protect and Repair Myelin Forming Cells ANAVEX®2-73
About this update from Anavex Life Sciences Corp.
[{"type":"text","content":"Published in Journal of Neuroimmunology, Results Highlight ANAVEX®2-73 (blarcamesine) Shown to Protect and Repair Myelin Forming Cells\n ANAVEX®2-73 (blarcamesine) Provides optimal Protection of Oligodendroglia against Glutamate Toxicity NEW YORK, Feb. 24, 2020 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders including Alzheimer’s disease, Parkinson’s disease, Rett syndrome and other central nervous system (CNS) diseases, today announced the publication in the peer-reviewed Journal of Neuroimmunology, titled “Sigma-1 Receptor Agonists as Potential Protective Therapies in Multiple Sclerosis“ featuring preclinical data of ANAVEX®2-73 (blarcamesine) relevant to multiple sclerosis. “A unique feature of ANAVEX®2-73 (blarcamesine), compared to another sigma-1 receptor agonist we studied, is that while these molecules increase proliferation of oligodendrocyte precursor cells (OPCs), ANAVEX®2-73 (blarcamesine) does not inhibit the maturation of these OPCs to oligodendrocytes (OLs), also called oligodendroglia”, said Professor Robert P. Lisak, MD the Parker Webber Chair in Neurology, Professor of Neurology and Professor of Biochemistry, Microbiology and Immunology at Wayne State University School of Medicine and lead author of the paper. “This is an important feature since OPCs can replace lost OLs by maturing into new potential myelin-producing cells. In other words, ANAVEX®2-73 (blarcamesine) might promote remyelination by both providing more OPCs and not delaying their maturation into mature OLs. Further data also demonstrates that ANAVEX®2-73 (blarcamesine) provides protection for OLs, OPCs, as well as central nervous system neurons in addition to helping repair by increasing the pool of OPCs that can go on to matter to OLs.“ Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, loss of oligodendrocytes (OLs) and axonal damage in the white matter accompanied by reactivity of astrocytes and microglia. There are effective disease-modifying therapies (DMTs) approved for treatment of patients with relapsing remitting MS, however, none of these DMTs are cures and many have s...