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Avant Diagnostics Presented Data on TheraLink® Pancreatic Cancer Assay at the International Symposium on Pancreas Cancer 2016
Avant Diagnostics Presented Data on TheraLink® Pancreatic Cancer Assay at the International Symposium on Pancreas Cancer 2016.
About this update from Amarantus Bioscience Holdings, Inc.
[{"type":"text","content":"\n\n SCOTTSDALE, Ariz. and GAITHERSBERG, Md., June 14, 2016 (GLOBE NEWSWIRE) -- Avant Diagnostics, Inc. (“Avant”) (OTCQB:AVDX), an innovative molecular diagnostics company, today announced that Dr. Vince Picozzi presented data on use of the Company’s TheraLink® assay in pancreatic cancer at the International Symposium on Pancreas Cancer 2016.\n “The presentation of data by D. Picozzi demonstrating that information on the activation status of signaling pathways, as provided by the technology behind our TheraLink® tests, prior to adjuvant therapy could enhance current prognostic models and/or identify new pharmacological targets is an important step forward as we validate additional applications for TheraLink® beyond breast cancer,” said Glenn Hoke, PhD, incoming Chief Scientific Officer at Avant. PRESENTATION DETAILSMeeting: Pancreas 2016: International Symposium on Pancreatic Cancer in Glasgow, ScotlandWhen: Thu 9 June 2016 - Sun 12 June 2016Abstract Title: Association of long-term survival in pancreatic cancer (PDAC) with increased proliferative and anti-apoptotic protein activation.Authors: Vincent J. Picozzi, Corinne Ramos, Nicholas N. Hoke, Glenn D. Hoke; Virginia Mason Medical Center, Seattle, WA; Theranostics Health, Inc., Rockville, MD; Theranostics Health, Rockville, MDBackground: 5 year (yr) overall survival (OS) for resected PDAC is typically 20%. To test the potential for molecular prediction of > 5 yr OS in such patients (pts), we analyzed proteomic activation (phosphorylation) patterns in both cancer and stromal cells from initial surgical specimens prior to adjuvant therapy (Rx). Methods: Formalin-fixed, paraffin-embedded tissue from 40 pts (20 pts each with long-term actual disease-free OS [median 65 mo, range 26-137 mo] [LTS] and with early relapse/death < 2 yrs [STS]) with de novo resected PDAC formed the test cohort. All pts received adjuvant Rx (chemo Rx with/without chemoradiation). Laser Capture Microdissection enabled directed cancer and stromal cell isolation. Retrospective blinded protein activation analysis for both was performed via Reverse Phase Protein Array (RPPA). Differences in baseline protein signaling of LTS vs. STS were evaluated via two-way ANOVA analysis. Results: Analysis of > 50 signal transduction proteins ...